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Consolidated Statements of Operations (unaudited) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Revenues:    
Net product revenue $ 55,981 $ 26,442
Collaboration and grant revenue 81 105
Total revenues 56,062 26,547
Operating expenses:    
Cost of product sales, excluding amortization of acquired intangible asset 3,045 39
Amortization of acquired intangible asset 5,428 0
Research and development 31,363 27,363
Selling, general and administrative 32,969 25,500
Total operating expenses 72,805 52,902
Loss from operations (16,743) (26,355)
Interest expense, net (3,303) (2,219)
Other income (expense), net 1,004 (318)
Loss before income tax expense (19,042) (28,892)
Income tax expense (221) (165)
Net loss attributable to common stockholders $ (19,263) $ (29,057)
Weighted-average shares outstanding:    
Basic and diluted (in shares) 41,626,617 34,305,948
Net loss per share-basic and diluted (in dollars per share)    
Net loss per share—basic and diluted (in dollars per share) $ (0.46) $ (0.85)