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Revenue recognition - Income Statement Impacts (Details) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Revenues:    
Net product revenue $ 55,981 $ 26,442
Collaboration and grant revenue 81 105
Total revenues 56,062 26,547
Operating expenses:    
Cost of product sales, excluding amortization of acquired intangible asset 3,045 39
Amortization of acquired intangible asset 5,428 0
Research and development 31,363 27,363
Selling, general and administrative 32,969 25,500
Total operating expenses 72,805 52,902
Loss from operations (16,743) (26,355)
Interest expense, net (3,303) (2,219)
Other income (expense), net 1,004 (318)
Loss before income tax expense (19,042) (28,892)
Income tax expense (221) (165)
Net loss attributable to common stockholders (19,263) $ (29,057)
Adjustments | ASU 2014-09    
Revenues:    
Net product revenue (829)  
Collaboration and grant revenue 0  
Total revenues (829)  
Operating expenses:    
Cost of product sales, excluding amortization of acquired intangible asset (80)  
Amortization of acquired intangible asset 0  
Research and development 0  
Selling, general and administrative 0  
Total operating expenses (80)  
Loss from operations (749)  
Interest expense, net 0  
Other income (expense), net 0  
Loss before income tax expense (749)  
Income tax expense 0  
Net loss attributable to common stockholders (749)  
Balances without adoption of Topic 606    
Revenues:    
Net product revenue 55,152  
Collaboration and grant revenue 81  
Total revenues 55,233  
Operating expenses:    
Cost of product sales, excluding amortization of acquired intangible asset 2,965  
Amortization of acquired intangible asset 5,428  
Research and development 31,363  
Selling, general and administrative 32,969  
Total operating expenses 72,725  
Loss from operations (17,492)  
Interest expense, net (3,303)  
Other income (expense), net 1,004  
Loss before income tax expense (19,791)  
Income tax expense (221)  
Net loss attributable to common stockholders $ (20,012)