The impact of adoption using the modified retrospective method on the Company’s consolidated financial statements is as follows:

i.Consolidated balance sheets



	Impact of changes in accounting policies
	As reported June 30, 2018			Adjustments			As reported Balances without adoption of Topic 606
Assets
Current assets:
Cash and cash equivalents	$	223,788		$	—		$	223,788
Marketable securities	72,318			—			72,318
Trade receivables, net	59,383			—			59,383
Inventory	13,852			(67		)	13,785
Prepaid expenses and other current assets	6,305			—			6,305
Total current assets	375,646			(67		)	375,579
Fixed assets, net	8,217			—			8,217
Intangible assets, net	126,290			—			126,290
Deposits and other assets	1,620			—			1,620
Total assets	$	511,773		$	(67	)	$	511,706
Liabilities and stockholders’ equity
Current liabilities:
Accounts payable and accrued expenses	$	82,534		$	(649	)	$	81,885
Current portion of long-term debt	1,666			—			1,666
Deferred revenue	—			4,141			4,141
Other current liabilities	2,274			—			2,274
Total current liabilities	86,474			3,492			89,966
Deferred revenue - long-term	10,540			—			10,540
Long-term debt	147,204			—			147,204
Other long-term liabilities	153			—			153
Total liabilities	244,371			3,492			247,863

Stockholders’ equity:
Common stock	47			—			47
Additional paid-in capital	1,105,124			—			1,105,124
Accumulated other comprehensive income	1,855			—			1,855
Accumulated deficit	(839,624		)	(3,559		)	(843,183		)
Total stockholders’ equity	267,402			(3,559		)	263,843
Total liabilities and stockholders’ equity	$	511,773		$	(67	)	$	511,706

ii.Consolidated statements of operations



	Impact of changes in accounting policies Three Months Ended
	As reported for the period ended June 30, 2018			Adjustments		As reported Balances without adoption of Topic 606
Revenues:
Net product revenue	$	68,170		$	604	$	68,774
Collaboration and grant revenue	573			—		573
Total revenues	68,743			604		69,347
Operating expenses:
Cost of product sales, excluding amortization of acquired intangible asset	2,572			13		2,585
Amortization of acquired intangible asset	5,593			—		5,593
Research and development	32,607			—		32,607
Selling, general and administrative	33,545			—		33,545
Total operating expenses	74,317			13		74,330
Loss from operations	(5,574		)	591		(4,983		)
Interest expense, net	(2,884		)	—		(2,884		)
Other expense, net	(673		)	—		(673		)
Loss before income tax expense	(9,131		)	591		(8,540		)
Income tax expense	(389		)	—		(389		)
Net loss attributable to common stockholders	$	(9,520	)	$	591	$	(8,929	)



	Impact of changes in accounting policies Year to Date
	As reported for the period ended June 30, 2018			Adjustments			As reported Balances without adoption of Topic 606
Revenues:
Net product revenue	$	124,151		$	(225	)	$	123,926
Collaboration and grant revenue	654			—			654
Total revenues	124,805			(225		)	124,580
Operating expenses:
Cost of product sales, excluding amortization of acquired intangible asset	5,616			(67		)	5,549
Amortization of acquired intangible asset	11,022			—			11,022
Research and development	63,970			—			63,970
Selling, general and administrative	66,514			—			66,514
Total operating expenses	147,122			(67		)	147,055
Loss from operations	(22,317		)	(158		)	(22,475		)
Interest expense, net	(6,187		)	—			(6,187		)
Other income, net	332			—			332
Loss before income tax expense	(28,172		)	(158		)	(28,330		)
Income tax expense	(610		)	—			(610		)
Net loss attributable to common stockholders	$	(28,782	)	$	(158	)	$	(28,940	)

iii.Consolidated statements of comprehensive loss



	Impact of changes in accounting policies Three Months Ended
	As reported for the period ended June 30, 2018			Adjustments		As reported Balances without adoption of Topic 606
Net loss	$	(9,520	)	$	591	$	(8,929	)
Other comprehensive loss:
Unrealized gain on marketable securities, net of tax	40			—		40
Foreign currency translation loss	(3,138		)	—		(3,138		)
Comprehensive loss	$	(12,618	)	$	591	$	(12,027	)



	Impact of changes in accounting policies Year to Date
	As reported for the period ended June 30, 2018			Adjustments			As reported Balances without adoption of Topic 606
Net loss	$	(28,782	)	$	(158	)	$	(28,940	)
Other comprehensive loss:
Unrealized loss on marketable securities, net of tax	(83		)	—			(83		)
Foreign currency translation loss	(2,031		)	—			(2,031		)
Comprehensive loss	$	(30,896	)	$	(158	)	$	(31,054	)

iv.Consolidated statements of cash flows



	Impact of changes in accounting policies
	As reported for the period ended June 30, 2018			Adjustments			Balances without adoption of Topic 606
Cash flows from operating activities
Net loss	$	(28,782	)	$	(158	)	$	(28,940	)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	12,243			—			12,243
Change in valuation of warrant liability	—			—			—
Non-cash interest expense	3,644			—			3,644
Loss on disposal of asset	—			—			—
Amortization of premiums and accretion of discounts on investments, net	(230		)	—			(230		)
Amortization of debt issuance costs	256			—			256
Share-based compensation expense	15,831			—			15,831
Benefit for deferred income taxes	—			—			—
Unrealized foreign currency transaction losses, net	(764		)	—			(764		)
Changes in operating assets and liabilities:							0
Inventory, net	(3,393		)	(67		)	(3,460		)
Prepaid expenses and other current assets	254			—			254
Trade receivables, net	(20,429		)	—			(20,429		)
Deposits and other assets	(419		)	—			(419		)
Accounts payable and accrued expenses	2,225			(649		)	1,576
Other liabilities	485			—			485
Deferred revenue	3,204			874			4,078
Net cash used in operating activities	(15,875		)	—			(15,875		)
Cash flows from investing activities
Purchases of fixed assets	(1,187		)	—			(1,187		)
Purchases of marketable securities	(28,656		)	—			(28,656		)
Sale and redemption of marketable securities	35,939			—			35,939
Acquisition, including transaction costs	—			—			—
Net cash provided by investing activities	6,096			—			6,096
Cash flows from financing activities
Proceeds from exercise of options	3,592			—			3,592
Net proceeds from public offerings	117,874			—			117,874
Proceeds from shares issued under employee stock purchase plan	1,299			—			1,299
Debt issuance costs related to secured term loan	—			—			—
Proceeds from issuance of secured term loan	—			—			—
Debt issuance costs related to convertible notes	—			—			—
Proceeds from issuance of convertible notes	—			—			—
Net cash provided by financing activities	122,765			—			122,765
Effect of exchange rate changes on cash	(990		)	—			(990		)
Net increase in cash and cash equivalents	111,996			—			111,996
Cash and cash equivalents, beginning of period	111,792			—			111,792
Cash and cash equivalents, end of period	$	223,788		$	—		$	223,788