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Consolidated Statements of Operations (unaudited) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Revenues:
Revenue	$ 68,743	$ 47,962	$ 124,805	$ 74,510
Operating expenses:
Cost of product sales, excluding amortization of acquired intangible asset	2,572	758	5,616	797
Amortization of acquired intangible asset	5,593	0	11,022	0
Research and development	32,607	30,835	63,970	58,198
Selling, general and administrative	33,545	28,866	66,514	54,365
Total operating expenses	74,317	60,459	147,122	113,360
Loss from operations	(5,574)	(12,497)	(22,317)	(38,850)
Interest expense, net	(2,884)	(3,008)	(6,187)	(5,227)
Other (expense) income, net	(673)	(1,820)	332	(2,139)
Loss before income tax expense	(9,131)	(17,325)	(28,172)	(46,216)
Income tax expense	(389)	(150)	(610)	(316)
Net loss attributable to common stockholders	$ (9,520)	$ (17,475)	$ (28,782)	$ (46,532)
Weighted-average shares outstanding:
Basic and diluted (in shares)	46,137,833	39,621,738	46,257,397	36,978,528
Net loss per share-basic and diluted (in dollars per share)
Net loss per share—basic and diluted (in dollars per share)	$ (0.21)	$ (0.44)	$ (0.62)	$ (1.26)
Product
Revenues:
Revenue	$ 68,170	$ 47,891	$ 124,151	$ 74,334
Collaboration and grant revenue
Revenues:
Revenue	$ 573	$ 71	$ 654	$ 176

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