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Stock award plan - Share Base Compensation (Details) - Stock option
$ / shares in Units, $ in Thousands
6 Months Ended
Jun. 30, 2018
USD ($)
$ / shares
shares
Number of options  
Outstanding at the beginning of the period (in shares) | shares 6,448,642
Granted (in shares) | shares 2,247,739
Exercised (in shares) | shares (260,879)
Forfeited/Cancelled (in shares) | shares (269,099)
Outstanding at the end of the period (in shares) | shares 8,166,403
Vested or Expected to vest at the end of the period (in shares) | shares 3,586,552
Exercisable at the end of the period (in shares) | shares 4,313,766
Weighted- average exercise price  
Outstanding at the beginning of the period (in dollars per share) | $ / shares $ 29.00
Granted (in dollars per share) | $ / shares 20.67
Exercised (in dollars per share) | $ / shares 13.77
Forfeited/Cancelled (in dollars per share) | $ / shares 33.12
Outstanding at the end of the period (in dollars per share) | $ / shares 27.06
Vested or Expected to vest at the end of the period (in dollars per share) | $ / shares 21.60
Exercisable at the end of the period (in dollars per share) | $ / shares $ 32.03
Weighted- average remaining contractual term  
Outstanding at the end of the period 7 years 6 months 18 days
Vested or Expected to vest at the end of the period 8 years 10 months 24 days
Exercisable at the end of the period 6 years 3 months 26 days
Aggregate intrinsic value  
Outstanding at the end of the period (in dollars) | $ $ 90,372
Vested or Expected to vest at the end of the period (in dollars) | $ 48,673
Exercisable at the end of the period (in dollars) | $ $ 37,911
Minimum  
Valuation assumptions  
Risk-free interest rate (as a percent) 2.25%
Expected volatility (as a percent) 64.00%
Expected term 5 years 16 days
Maximum  
Valuation assumptions  
Risk-free interest rate (as a percent) 2.89%
Expected volatility (as a percent) 90.00%
Expected term 10 years