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Revenue recognition - Income Statement Impacts (Details) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Dec. 31, 2017
Revenues:          
Revenue $ 68,743 $ 47,962 $ 124,805 $ 74,510  
Operating expenses:          
Cost of product sales, excluding amortization of acquired intangible asset 2,572 758 5,616 797  
Inventory 13,852   13,852   $ 10,754
Amortization of acquired intangible asset 5,593 0 11,022 0  
Research and development 32,607 30,835 63,970 58,198  
Selling, general and administrative 33,545 28,866 66,514 54,365  
Total operating expenses 74,317 60,459 147,122 113,360  
Loss from operations (5,574) (12,497) (22,317) (38,850)  
Interest expense, net (2,884) (3,008) (6,187) (5,227)  
Other (expense) income, net (673) (1,820) 332 (2,139)  
Loss before income tax expense (9,131) (17,325) (28,172) (46,216)  
Income tax expense (389) (150) (610) (316)  
Net loss attributable to common stockholders (9,520) (17,475) (28,782) (46,532)  
Adjustments | ASU 2014-09          
Revenues:          
Revenue 604   (225)    
Operating expenses:          
Amortization of acquired intangible asset 0   0    
Research and development 0   0    
Selling, general and administrative 0   0    
Total operating expenses 13   (67)    
Loss from operations 591   (158)    
Interest expense, net 0   0    
Other (expense) income, net 0   0    
Loss before income tax expense 591   (158)    
Income tax expense 0   0    
Net loss attributable to common stockholders 591   (158)    
Balances without adoption of Topic 606          
Revenues:          
Revenue 69,347   124,580    
Operating expenses:          
Inventory 13,785   13,785    
Amortization of acquired intangible asset 5,593   11,022    
Research and development 32,607   63,970    
Selling, general and administrative 33,545   66,514    
Total operating expenses 74,330   147,055    
Loss from operations (4,983)   (22,475)    
Interest expense, net (2,884)   (6,187)    
Other (expense) income, net (673)   332    
Loss before income tax expense (8,540)   (28,330)    
Income tax expense (389)   (610)    
Net loss attributable to common stockholders (8,929)   (28,940)    
Product          
Revenues:          
Revenue 68,170 47,891 124,151 74,334  
Product | Adjustments | ASU 2014-09          
Revenues:          
Revenue 604   (225)    
Operating expenses:          
Cost of product sales, excluding amortization of acquired intangible asset 13        
Inventory (67)   (67)    
Product | Balances without adoption of Topic 606          
Revenues:          
Revenue 68,774   123,926    
Operating expenses:          
Cost of product sales, excluding amortization of acquired intangible asset 2,585   5,549    
Collaboration and grant revenue          
Revenues:          
Revenue 573 $ 71 654 $ 176  
Collaboration and grant revenue | Adjustments | ASU 2014-09          
Revenues:          
Revenue 0   0    
Collaboration and grant revenue | Balances without adoption of Topic 606          
Revenues:          
Revenue $ 573   $ 654