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Commitments and contingencies (Details) $ in Millions | 9 Months Ended |  |
--- | --- | --- | ---
Sep. 30, 2018 USD ($) claim | Aug. 23, 2018 USD ($) | Jun. 30, 2016 USD ($)
Other Commitments [Abstract] |  |  |
Development milestone payments which the entity is obligated to pay | $ 4.5 |  |
Claims settled and dismissed | claim | 2 |  |
Akcea |  |  |
Other Commitments [Abstract] |  |  |
Upfront licensing fee | $ 12.0 |  |
Development and regulatory milestone payment obligations, period | 30 days |  |
Milestone, potential achievements, regulatory approval | $ 4.0 |  |
Akcea | Maximum |  |  |
Other Commitments [Abstract] |  |  |
Milestone, potential achievements, regulatory approval | 8.0 |  |
Funding agreement | Wellcome trust |  |  |
Other Commitments [Abstract] |  |  |
Development milestone payments which the entity is obligated to pay |  |  | $ 0.8
Funding agreement | Wellcome trust | Maximum |  |  |
Other Commitments [Abstract] |  |  |
Development milestone payments which the entity is obligated to pay | 22.4 |  |
Non-collaborative Arrangement Transactions | Akcea |  |  |
Other Commitments [Abstract] |  |  |
Development milestone payments which the entity is obligated to pay | 6.0 |  |
Agilis |  |  |
Other Commitments [Abstract] |  |  |
Development milestone payments which the entity is obligated to pay | 40.0 | $ 40.0 |
Agilis | Maximum |  |  |
Other Commitments [Abstract] |  |  |
Development milestone payments which the entity is obligated to pay | 60.0 |  |
Agilis | Non-collaborative Arrangement Transactions |  |  |
Other Commitments [Abstract] |  |  |
Development milestone payments which the entity is obligated to pay | $ 40.0 | $ 40.0 |

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