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Revenue recognition - Narrative (Details) |  | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | ---
Sep. 30, 2018 USD ($) | Oct. 31, 2017 USD ($) | Nov. 30, 2014 USD ($) | Jan. 31, 2014 USD ($) | Aug. 31, 2013 USD ($) | Nov. 30, 2011 USD ($) compound | Sep. 30, 2018 USD ($) | Sep. 30, 2018 USD ($) deliverable segment | Sep. 30, 2017 USD ($) | Dec. 31, 2017 deliverable
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |
Number of operating segments | segment |  |  |  |  |  |  |  | 1 |  |
Net product revenue |  |  |  |  |  |  | $ 53,021,000 | $ 177,172,000 |  |
Upfront cash payment |  |  |  |  |  |  |  | 4,706,000 |  |
Performance obligations satisfied in current period |  |  |  |  |  |  | 53,021,000 | 177,172,000 |  |
Licensing And Collaboration Agreement |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |
Upfront cash payment |  |  |  |  |  | $ 30,000,000 |  |  |  |
Performance obligations satisfied in current period |  | $ 20,000,000 | $ 10,000,000 | $ 7,500,000 | $ 10,000,000 |  |  |  |  |
Revenues |  |  |  |  |  |  |  | 200,000 | $ 200,000 |
Licensing And Collaboration Agreement | Research And Development Event Milestones |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |
Revenue recognition, milestone, potential achievements | $ 87,500,000 |  |  |  |  |  |  | 135,000,000 |  |
Licensing And Collaboration Agreement | Sales Milestones |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |
Revenue recognition, milestone, potential achievements |  |  |  |  |  |  |  | 325,000,000 |  |
Discovery Agreements |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  | 0 | 0 |
Early Stage Collaborations |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  | 0 | $ 0 |
Early Stage Collaborations | Research And Development Event Milestones |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |
Revenue recognition, milestone, potential achievements |  |  |  |  |  |  |  | 143,000,000 |  |
Early Stage Collaborations | Sales Milestones |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |
Revenue recognition, milestone, potential achievements |  |  |  |  |  |  |  | 252,000,000 |  |
United States |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |
Net product revenue |  |  |  |  |  |  | 22,600,000 | 62,200,000 |  |
Non-US |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |
Net product revenue |  |  |  |  |  |  | $ 30,400,000 | $ 115,000,000 |  |
Collaborative Arrangement | Roche And Sma Foundation |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |
Number of compounds in preclinical development | compound |  |  |  |  |  | 3 |  |  |  |
Number of significant deliverables | deliverable |  |  |  |  |  |  |  |  |  | 2
Collaboration And Discovery Agreements |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |
Number of significant deliverables | deliverable |  |  |  |  |  |  |  | 2 |  |
Minimum | Collaboration And Discovery Agreements |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |
Collaborative arrangements research period for applying discovery technology |  |  |  |  |  |  |  | 3 years |  |
Maximum | Collaboration And Discovery Agreements |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |
Collaborative arrangements research period for applying discovery technology |  |  |  |  |  |  |  | 4 years |  |

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