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v3.10.0.1

Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2018 | Sep. 30, 2017
Cash flows from operating activities |  |
Net loss | $ (79,751) | $ (80,270)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 19,316 | 11,743
Change in valuation of warrant liability | 3 | 3
Non-cash interest expense | 5,563 | 4,999
Loss on disposal of asset | 2 | 5
Amortization of premiums and accretion of discounts on investments, net | (354) | 493
Amortization of debt issuance costs | 390 | 308
Share-based compensation expense | 24,773 | 24,082
Unrealized foreign currency transaction gains | (977) | (364)
Changes in operating assets and liabilities: |  |
Inventory | (3,252) | (3,625)
Prepaid expenses and other current assets | (1,301) | (570)
Trade receivables, net | (2,681) | (10,994)
Deposits and other assets | (385) | (485)
Accounts payable and accrued expenses | 18,606 | 11,807
Other liabilities | 1,617 | 807
Deferred revenue | 5,933 | 10,710
Net cash used in operating activities | (12,498) | (31,351)
Cash flows from investing activities |  |
Purchases of fixed assets | (2,489) | (1,058)
Purchases of marketable securities | (28,656) | (19,467)
Sale and redemption of marketable securities | 65,923 | 164,847
Acquisition of product rights | (3,903) | (77,163)
Business acquisition, net of cash acquired | (48,892) | 0
Net cash (used in) / provided by investing activities | (18,017) | 67,159
Cash flows from financing activities |  |
Proceeds from exercise of options | 8,631 | 1,437
Net proceeds from public offerings | 117,915 | 0
Proceeds from shares issued under employee stock purchase plan | 1,299 | 1,362
Debt issuance costs related to secured term loan | 0 | (432)
Proceeds from issuance of secured term loan | 0 | 40,000
Net cash provided by financing activities | 127,845 | 42,367
Effect of exchange rate changes on cash | (2,209) | 5,342
Net increase in cash and cash equivalents | 95,121 | 83,517
Cash and cash equivalents, beginning of period | 111,792 | 58,321
Cash and cash equivalents, end of period | 206,913 | 141,838
Supplemental disclosure of cash information |  |
Cash paid for interest | 6,927 | 5,496
Cash paid for income taxes | 919 | 616
Supplemental disclosure of non-cash investing and financing activity |  |
Unrealized gain (loss) on marketable securities | (50) | 0
Acquisition of product rights and licenses | $ (4,530) | $ 0

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- Definition The cash outflow paid to third parties in connection with debt origination, which will be amortized over the remaining maturity period of the associated long-term debt. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3291-108585 + Details
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- Definition The cash outflow associated with the acquisition of a business, net of the cash acquired from the purchase. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3213-108585 + Details
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- Definition Amount of cash outflow for purchase of marketable security. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=109979856&loc=d3e26853-111562 + Details
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- Definition The cash outflow for purchases of and capital improvements on property, plant and equipment (capital expenditures), software, and other intangible assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3213-108585 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3213-108585 + Details
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- Definition The cash inflow from the issuance of a long-term debt instrument which can be exchanged for a specified amount of another security, typically the entity's common stock, at the option of the issuer or the holder. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with the aggregate amount received by the entity through sale or maturity of marketable securities (held-to-maturity or available-for-sale) during the period. + References No definition available. + Details
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- Definition Amount of cash inflow from exercise of stock options granted under share-based compensation arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2A -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109197908&loc=SL79508275-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with the amount received from the stock plan during the period. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3602-108585 + Details
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