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Stock award plan (Tables)

9 Months Ended

Sep. 30, 2018

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Summary of stock option activity

A summary of stock option activity is as follows:

		Number of options			Weighted- average exercise price				Weighted- average remaining contractual term		Aggregate intrinsic value
											(in thousands)
Outstanding at December 31, 2017		6,448,642			$	29.00
Granted		2,914,139			$	25.84
Exercised		512,145			$	17.03
Forfeited/Cancelled		(329,404	)		$	34.20
Outstanding at September 30, 2018		9,545,522			$	28.44			7.45 years		$	172,859
Vested or Expected to vest at September 30, 2018		3,914,413			$	24.38			8.93 years		$	89,547
Exercisable at September 30, 2018		4,316,071			$	32.33			5.99 years		$	77,003

Schedule of assumptions used to estimate fair values of grants made on the date of grant

The fair value of grants made in the nine months ended September 30, 2018 was contemporaneously estimated on the date of grant using the following assumptions:

		Nine months ended September 30, 2018
Risk-free interest rate		2.25%—3.03%
Expected volatility		64%—90%
Expected term		5.04 – 10.00 years

Summary of information on the Company's restricted stock

The following table summarizes information on the Company’s restricted stock awards and units:

		Restricted Stock Awards and Units
		Number of Shares			Weighted Average Grant Date Fair Value
January 1, 2018		393,011			$	15.64
Granted		354,691			$	19.09
Vested		(113,795	)		$	16.36
Forfeited		(53,560	)		$	17.24
Unvested at September 30, 2018		580,347			$	17.60

Schedule of share-based compensation expense recorded in the statement of operations

The Company recorded share-based compensation expense in the statement of operations related to incentive stock options, nonstatutory stock options, restricted stock awards, restricted stock units and the ESPP as follows:

		Three Months Ended September 30,								Nine Months Ended September 30,
		2018				2017				2018				2017
Research and development		$	4,431			$	3,624			$	12,109			$	11,986
Selling, general and administrative		4,511				3,544				12,664				12,096
Total		$	8,942			$	7,168			$	24,773			$	24,082

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Tabular disclosure of the changes in outstanding nonvested restricted stock shares.

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Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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