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The Company (Details) $ in Thousands			1 Months Ended	9 Months Ended
	Aug. 23, 2018 USD ($) shares	Apr. 20, 2017 USD ($) shares	Aug. 31, 2014 member_state	Sep. 30, 2018 USD ($) product country	Dec. 31, 2017 USD ($)	Aug. 31, 2015
Long-term debt
Number of products | product				2
Number of member states of the European Economic Area | member_state			31
Development milestone payments which the entity is obligated to pay				$ 4,500
Retained earnings (accumulated deficit)				$ (890,593)	$ (814,108)
Convertible debt | 3.00% Convertible senior notes due 2022
Long-term debt
Interest rate						3.00%
Non-collaborative Arrangement Transactions | Marathon Pharmaceuticals, LLC
Long-term debt
Cash consideration		$ 75,000
Equity Interest Issued, number of shares (in shares) | shares		6,683,598
Numerator for calculation of number of shares of equity interests issued to acquire entity		$ 65,000
Trading day period		15 days
Development milestone payments which the entity is obligated to pay		$ 50,000
Translarna
Long-term debt
Number of countries | country				25
Agilis
Long-term debt
Cash consideration	$ 49,221
Equity Interest Issued, number of shares (in shares) | shares	3,500,907
Numerator for calculation of number of shares of equity interests issued to acquire entity	$ 150,000
Trading day period	10 days
Development milestone payments which the entity is obligated to pay	$ 40,000			$ 40,000
Agilis | Non-collaborative Arrangement Transactions
Long-term debt
Development milestone payments which the entity is obligated to pay	$ 40,000			$ 40,000

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