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Consolidated Statements of Operations (unaudited) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Revenues:
Revenue	$ 53,591	$ 41,853	$ 178,396	$ 116,362
Operating expenses:
Cost of product sales, excluding amortization of acquired intangible asset	3,292	1,582	8,909	2,142
Amortization of acquired intangible asset	5,793	9,716	16,815	9,952
Research and development	54,368	30,024	118,337	88,222
Selling, general and administrative	38,368	31,423	104,882	85,788
Total operating expenses	101,821	72,745	248,943	186,104
Loss from operations	(48,230)	(30,892)	(70,547)	(69,742)
Interest expense, net	(3,118)	(3,421)	(9,306)	(8,648)
Other income (expense), net	734	766	1,066	(1,373)
Loss before income tax expense	(50,614)	(33,547)	(78,787)	(79,763)
Income tax expense	(355)	(191)	(964)	(507)
Net loss attributable to common stockholders	$ (50,969)	$ (33,738)	$ (79,751)	$ (80,270)
Weighted-average shares outstanding:
Basic and diluted (in shares)	48,096,521	41,296,740	45,310,690	38,433,749
Net loss per share-basic and diluted (in dollars per share)
Net loss per share—basic and diluted (in dollars per share)	$ (1.06)	$ (0.82)	$ (1.76)	$ (2.09)
Product
Revenues:
Revenue	$ 53,021	$ 41,780	$ 177,172	$ 116,113
Collaboration and grant revenue
Revenues:
Revenue	$ 570	$ 73	$ 1,224	$ 249

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