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Stock award plan - Share Base Compensation (Details) - Stock option
$ / shares in Units, $ in Thousands
9 Months Ended
Sep. 30, 2018
USD ($)
$ / shares
shares
Number of options  
Outstanding at the beginning of the period (in shares) | shares 6,448,642
Granted (in shares) | shares 2,914,139
Exercised (in shares) | shares 512,145
Forfeited/Cancelled (in shares) | shares (329,404)
Outstanding at the end of the period (in shares) | shares 9,545,522
Vested or Expected to vest at the end of the period (in shares) | shares 3,914,413
Exercisable at the end of the period (in shares) | shares 4,316,071
Weighted- average exercise price  
Outstanding at the beginning of the period (in dollars per share) | $ / shares $ 29.00
Granted (in dollars per share) | $ / shares 25.84
Exercised (in dollars per share) | $ / shares 17.03
Forfeited/Cancelled (in dollars per share) | $ / shares 34.20
Outstanding at the end of the period (in dollars per share) | $ / shares 28.44
Vested or Expected to vest at the end of the period (in dollars per share) | $ / shares 24.38
Exercisable at the end of the period (in dollars per share) | $ / shares $ 32.33
Weighted- average remaining contractual term  
Outstanding at the end of the period 7 years 5 months 12 days
Vested or Expected to vest at the end of the period 8 years 11 months 5 days
Exercisable at the end of the period 5 years 11 months 27 days
Aggregate intrinsic value  
Outstanding at the end of the period (in dollars) | $ $ 172,859
Vested or Expected to vest at the end of the period (in dollars) | $ 89,547
Exercisable at the end of the period (in dollars) | $ $ 77,003
Minimum  
Valuation assumptions  
Risk-free interest rate (as a percent) 2.25%
Expected volatility (as a percent) 64.00%
Expected term 5 years 16 days
Maximum  
Valuation assumptions  
Risk-free interest rate (as a percent) 3.03%
Expected volatility (as a percent) 90.00%
Expected term 10 years