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Revenue recognition - Income Statement Impacts (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Revenues:        
Revenue $ 53,591 $ 41,853 $ 178,396 $ 116,362
Operating expenses:        
Cost of product sales, excluding amortization of acquired intangible asset 3,292 1,582 8,909 2,142
Amortization of acquired intangible asset 5,793 9,716 16,815 9,952
Research and development 54,368 30,024 118,337 88,222
Selling, general and administrative 38,368 31,423 104,882 85,788
Total operating expenses 101,821 72,745 248,943 186,104
Loss from operations (48,230) (30,892) (70,547) (69,742)
Interest expense, net (3,118) (3,421) (9,306) (8,648)
Other income (expense), net 734 766 1,066 (1,373)
Loss before income tax expense (50,614) (33,547) (78,787) (79,763)
Income tax expense (355) (191) (964) (507)
Net loss attributable to common stockholders (50,969) (33,738) (79,751) (80,270)
Adjustments | ASU 2014-09        
Revenues:        
Revenue (834)   (1,059)  
Operating expenses:        
Cost of product sales, excluding amortization of acquired intangible asset (17)   (84)  
Amortization of acquired intangible asset 0   0  
Research and development 0   0  
Selling, general and administrative 0   0  
Total operating expenses (17)   (84)  
Loss from operations (817)   (975)  
Interest expense, net 0   0  
Other income (expense), net 0   0  
Loss before income tax expense (817)   (975)  
Income tax expense 0   0  
Net loss attributable to common stockholders (817)   (975)  
Balances without adoption of Topic 606        
Revenues:        
Revenue 52,757   177,337  
Operating expenses:        
Cost of product sales, excluding amortization of acquired intangible asset 3,275   8,825  
Amortization of acquired intangible asset 5,793   16,815  
Research and development 54,368   118,337  
Selling, general and administrative 38,368   104,882  
Total operating expenses 101,804   248,859  
Loss from operations (49,047)   (71,522)  
Interest expense, net (3,118)   (9,306)  
Other income (expense), net 734   1,066  
Loss before income tax expense (51,431)   (79,762)  
Income tax expense (355)   (964)  
Net loss attributable to common stockholders (51,786)   (80,726)  
Product        
Revenues:        
Revenue 53,021 41,780 177,172 116,113
Product | Adjustments | ASU 2014-09        
Revenues:        
Revenue (834)   (1,059)  
Product | Balances without adoption of Topic 606        
Revenues:        
Revenue 52,187   176,113  
Collaboration and grant revenue        
Revenues:        
Revenue 570 $ 73 1,224 $ 249
Collaboration and grant revenue | Adjustments | ASU 2014-09        
Revenues:        
Revenue 0   0  
Collaboration and grant revenue | Balances without adoption of Topic 606        
Revenues:        
Revenue $ 570   $ 1,224