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Fair value of financial instruments and investments - Fair Value Liabilities Measured (Details) | Dec. 31, 2018 USD ($) $ / shares | Dec. 31, 2017 USD ($) $ / shares | Dec. 31, 2016 USD ($)
--- | --- | --- | ---
Warrants |  |  |
Fair value of warrant liability |  |  |
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value | $ 0 | $ 1,000 |
Stock Appreciation Rights (SARs) |  |  |
Fair value of warrant liability |  |  |
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value | $ 3,814,000 | $ 1,665,000 |
Minimum | Warrants |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | $ / shares | 128.00 | 128.00 |
Minimum | Stock Appreciation Rights (SARs) |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | $ / shares | 6.76 | 6.76 |
Minimum | Volatility | Warrants |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 0.59 | 0.69 |
Minimum | Volatility | Stock Appreciation Rights (SARs) |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 0.47 | 0.31 |
Minimum | Risk free interest rate | Warrants |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 0.03 | 0.02 |
Minimum | Risk free interest rate | Stock Appreciation Rights (SARs) |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 0.02 | 0.01 |
Minimum | Expected life | Warrants |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 0.59 | 1.59 |
Minimum | Expected life | Stock Appreciation Rights (SARs) |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 0.01 | 0.00 |
Maximum | Warrants |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | $ / shares | 2,520.00 | 2,520.00 |
Maximum | Stock Appreciation Rights (SARs) |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | $ / shares | 30.86 | 30.86 |
Maximum | Volatility | Warrants |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 0.60 | 0.69 |
Maximum | Volatility | Stock Appreciation Rights (SARs) |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 0.60 | 0.70 |
Maximum | Risk free interest rate | Warrants |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 0.03 | 0.02 |
Maximum | Risk free interest rate | Stock Appreciation Rights (SARs) |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 0.03 | 0.02 |
Maximum | Expected life | Warrants |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 0.72 | 1.70 |
Maximum | Expected life | Stock Appreciation Rights (SARs) |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 1.01 | 2.00 |
Common stock | Fair value of common stock | Warrants |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | $ / shares | 34.32 | 16.68 |
Common stock | Fair value of common stock | Stock Appreciation Rights (SARs) |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | $ / shares | 34.32 | 16.68 |
Significant unobservable inputs (level 3) | Warrants |  |  |
Fair value of warrant liability |  |  |
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value | $ 0 | $ 1,000 | $ 1,000
Significant unobservable inputs (level 3) | Stock Appreciation Rights (SARs) |  |  |
Fair value of warrant liability |  |  |
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value | 3,814,000 | 1,665,000 | $ 865,000
Significant unobservable inputs (level 3) | Agilis |  |  |
Fair value of warrant liability |  |  |
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value | $ 53,200,000 |  |
Liability, Net Sales Milestones and Royalties | Minimum | Probabilities of success | Commitments [Member] |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 0.25 |  |
Liability, Net Sales Milestones and Royalties | Maximum | Probabilities of success | Commitments [Member] |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 0.89 |  |
Liability, Net Sales Milestones and Royalties | Agilis |  |  |
Fair value of warrant liability |  |  |
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value | $ 53,200,000 |  |
Liability, Net Sales Milestones and Royalties | Agilis | Minimum | Potential net sales milestones | Commitments [Member] |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 0 |  |
Liability, Net Sales Milestones and Royalties | Agilis | Minimum | Potential percentage of net sales for royalties | Commitments [Member] |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 0.02 |  |
Liability, Net Sales Milestones and Royalties | Agilis | Maximum | Potential net sales milestones | Commitments [Member] |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 150,000,000 |  |
Liability, Net Sales Milestones and Royalties | Agilis | Maximum | Potential percentage of net sales for royalties | Commitments [Member] |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 0.06 |  |
Liability, Net Sales Milestones and Royalties | Significant unobservable inputs (level 3) | Agilis |  |  |
Fair value of warrant liability |  |  |
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value | $ 53,200,000 | $ 0 |
Liability, Development and Regulatory Milestone | Minimum | Probabilities of success | Commitments [Member] |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 0.25 |  |
Liability, Development and Regulatory Milestone | Maximum | Probabilities of success | Commitments [Member] |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 0.89 |  |
Liability, Development and Regulatory Milestone | Agilis |  |  |
Fair value of warrant liability |  |  |
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value | $ 257,040,000 |  |
Liability, Development and Regulatory Milestone | Agilis | Minimum | Potential development and regulatory milestones | Commitments [Member] |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 0 |  |
Liability, Development and Regulatory Milestone | Agilis | Minimum | Discount rates | Commitments [Member] |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 0.058 |  |
Liability, Development and Regulatory Milestone | Agilis | Maximum | Potential development and regulatory milestones | Commitments [Member] |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 555,000,000 |  |
Liability, Development and Regulatory Milestone | Agilis | Maximum | Discount rates | Commitments [Member] |  |  |
Fair value of warrant liability |  |  |
Alternative Investment, Measurement Input | 0.080 |  |
Liability, Development and Regulatory Milestone | Significant unobservable inputs (level 3) | Agilis |  |  |
Fair value of warrant liability |  |  |
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value | $ 257,040,000 |  |

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