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Intangible assets and goodwill - Narrative (Details) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended |
--- | --- | --- | ---
Dec. 31, 2018 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016 | Apr. 20, 2017
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |
Useful life |  | 7 years |  |  |
Amortization of acquired intangible asset |  | $ 22,877 | $ 15,380 | $ 0 |
Total allocation of IPR&D assets |  | 576,500 |  |  |
Goodwill | $ 82,341 | 82,341 | 0 |  |
Goodwill Adjustment | 18,000 |  |  |  |
Akcea |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |
Upfront licensing fee |  | $ 12,000 |  |  |
Development And Regulatory Milestone Payment Obligations, Period |  | 30 days |  |  |
Non-collaborative Arrangement Transactions | Akcea |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |
Development milestone payment obligations | 6,000 | $ 6,000 |  |  |
Emflaza |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |
Development milestone payment obligations | 14,400 | 14,400 |  |  |
Emflaza asset acquisition |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Finite-Lived Intangibles |  |  |  |  | $ 148,400
Marathon Pharmaceuticals, LLC |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |
Development milestone payment obligations | 6,000 | 6,000 |  |  |
Intellectual Property |  |  |  |  |
Finite-Lived Intangible Assets [Line Items] |  |  |  |  |
Amortization of acquired intangible asset |  | 22,900 | $ 15,400 |  |
Finite-Lived Intangible Assets, Accumulated Amortization | $ 38,300 | $ 38,300 |  |  |

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- Definition The aggregate expense charged against earnings to allocate the cost of intangible assets (nonphysical assets not used in production) in a systematic and rational manner to the periods expected to benefit from such assets. As a noncash expense, this element is added back to net income when calculating cash provided by or used in operations using the indirect method. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3602-108585 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 30 -Section 50 -Paragraph 2 -Subparagraph (a)(2) -URI http://asc.fasb.org/extlink&oid=66006027&loc=d3e16323-109275 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 30 -Section 45 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6388964&loc=d3e16225-109274 + Details
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