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Selected quarterly financial data (Tables) | 12 Months Ended
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Dec. 31, 2018
Quarterly Financial Information Disclosure [Abstract] |
Summary of quarterly data | The following financial information reflects all normal recurring adjustments, which are, in the opinion of management, necessary for a fair statement of the results of the interim periods. Summarized quarterly data for 2018 and 2017 are as follows:
|  | For the quarters ending
|  | March 31 |  | June 30 |  | September 30 |  | December 31
2018: |  |  |  |  |  |  |  |  |  |  |  |
Net product revenue |  | $ | 55,981 |  |  | $ | 68,170 |  |  | $ | 53,021 |  |  | $ | 85,833 |
Collaboration and grant revenue |  | 81 |  |  | 573 |  |  | 570 |  |  | 505 |
Operating expenses |  | 72,805 |  |  | 74,317 |  |  | 101,821 |  |  | 131,476 |
Loss from operations |  | (16,743 | ) |  | (5,574 | ) |  | (48,230 | ) |  | (45,138 | )
Net loss |  | (19,263 | ) |  | (9,520 | ) |  | (50,969 | ) |  | (48,330 | )
Basic and diluted net loss per common share(1) |  | $ | (0.46 | ) |  | $ | (0.21 | ) |  | $ | (1.06 | ) |  | $ | (0.96 | )
2017: |  |  |  |  |  |  |  |  |  |  |  |
Net product revenue |  | $ | 26,442 |  |  | $ | 47,891 |  |  | $ | 41,780 |  |  | $ | 57,953 |
Collaboration and grant revenue |  | 105 |  |  | 71 |  |  | 73 |  |  | 20,077 |
Operating expenses |  | 52,902 |  |  | 60,459 |  |  | 72,745 |  |  | 72,578 |
(Loss) income from operations |  | (26,355 | ) |  | (12,497 | ) |  | (30,892 | ) |  | 5,452 |
Net (loss) income |  | (29,057 | ) |  | (17,475 | ) |  | (33,738 | ) |  | 1,270 |
Basic and diluted net (loss) income per common share(1)(2) |  | $ | (0.85 | ) |  | $ | (0.44 | ) |  | $ | (0.82 | ) |  | $ | 0.03 |
(1) | The amounts were computed independently for each quarter and the sum of the quarters may not total the annual amounts.
(2) | Diluted net income per common share for the quarter ending December 31, 2017 excludes the conversion of the Convertible Notes as the effect of their inclusion is anti-dilutive during the period.

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- Definition Tabular disclosure of quarterly financial data. Includes, but is not limited to, financial information for fiscal quarters, cumulative effect of a change in accounting principle and earnings per share data. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 270 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=109225645&loc=d3e1280-108306 + Details
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