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Income taxes - Narrative (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Operating loss carryforwards |  |  |
Valuation allowance | $ 180,481 | $ 177,631 |
Valuation allowance, deferred tax asset, increase (decrease) | 2,800 | $ 5,400 |
Deferred Tax Assets, Operating Loss Carryforwards, Limited by IRC Section 382 | 231,500 |  |
Orphan drug credit carryover | 74,000 |  |
Limited NOL carryforwards | 231,500 |  |
Operating loss carryforwards, not subject to expiration | 169,200 |  |
Operating loss carryforwards, subject to expiration | 62,300 |  |
Operating loss carryforwards for immediate use | 194,500 |  |
Operating loss carryforwards in next twelve months | $ 5,700 |  |
Federal income tax provision at statutory rate | 21.00% | 34.00% | 34.00%
Uncertain tax position | $ 0 |  |
Change In tax rate, deferred tax asset, provisional income tax expense | 46,100 |  |
First five years from ownership change |  |  |
Operating loss carryforwards |  |  |
Net operating loss carryforwards | 16,700 |  |
After five years |  |  |
Operating loss carryforwards |  |  |
Net operating loss carryforwards | 5,700 |  |
Federal |  |  |
Operating loss carryforwards |  |  |
Net operating loss carryforwards | 296,000 |  |
Research and development credit carryforwards | 15,200 |  |
State |  |  |
Operating loss carryforwards |  |  |
Net operating loss carryforwards | 202,400 |  |
Research and development credit carryforwards | 6,600 |  |
Foreign Tax Authority |  |  |
Operating loss carryforwards |  |  |
Net operating loss carryforwards | $ 5,900 |  |

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