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v3.10.0.1

Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands | Total | Common stock | Additional paid-in capital | Accumulated other comprehensive (loss) income | Accumulated deficit
--- | --- | --- | --- | --- | ---
Balance (in shares) at Dec. 31, 2015 |  | 33,916,559 |  |  |
Balance at the beginning of the period at Dec. 31, 2015 | $ 226,001 | $ 34 | $ 820,165 | $ (1,200) | $ (592,998)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Exercise of options (in shares) |  | 89,216 |  |  |
Exercise of options | 968 | $ 0 | 968 |  |
Restricted stock vesting and issuance (in shares) |  | 163,635 |  |  |
Restricted stock vesting and issuance | 0 |  |  |  |
Share-based compensation expense | 35,009 |  | 35,009 |  |
Net loss | (142,110) |  |  |  | (142,110)
Comprehensive loss | (285) |  |  | (285) |
Balance (in shares) at Dec. 31, 2016 |  | 34,169,410 |  |  |
Balance at the end of the period at Dec. 31, 2016 | 119,583 | $ 34 | 856,142 | (1,485) | (735,108)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock related to acquisition (in shares) |  | 6,683,598 |  |  |
Issuance of common stock related to acquisition | 75,191 | $ 7 | 75,184 |  |
Exercise of options (in shares) |  | 202,085 |  |  |
Exercise of options | 2,182 | $ 0 | 2,182 |  |
Restricted stock vesting and issuance (in shares) |  | 287,531 |  |  |
Restricted stock vesting and issuance | 1 | $ 1 |  |  |
Issuance of common stock in connection with an employee stock purchase plan (in shares) |  | 269,771 |  |  |
Issuance of common stock in connection with an employee stock purchase plan | 2,467 |  | 2,467 |  |
Share-based compensation expense | 30,559 |  | 30,559 |  |
Net loss | (79,000) |  |  |  | (79,000)
Comprehensive loss | 5,454 |  |  | 5,454 |
Balance (in shares) at Dec. 31, 2017 |  | 41,612,395 |  |  |
Balance at the end of the period at Dec. 31, 2017 | $ 156,437 | $ 42 | 966,534 | 3,969 | (814,108)
Common stock, authorized shares (in shares) | 125,000,000 |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock related to acquisition | $ 155,860 | $ 3 | 155,857 |  |
Issuance of common stock related to equity offering (in shares) |  | 4,600,000 |  |  |
Issuance of common stock related to equity offering | 117,916 | $ 5 | 117,911 |  |
Exercise of options (in shares) |  | 633,973 |  |  |
Exercise of options | 10,868 | $ 1 | 10,867 |  |
Restricted stock vesting and issuance (in shares) |  | 119,691 |  |  |
Restricted stock vesting and issuance | 0 | $ 0 |  |  |
Issuance of common stock in connection with an employee stock purchase plan (in shares) |  | 139,181 |  |  |
Issuance of common stock in connection with an employee stock purchase plan | 2,787 | $ 0 | 2,787 |  |
Share-based compensation expense | 33,252 |  | 33,252 |  |
Receivable from investor | 929 |  | 929 |  |
Net loss | (128,081) |  |  |  | (128,081)
Comprehensive loss | (2,507) |  |  | (2,507) |
Balance (in shares) at Dec. 31, 2018 |  | 50,606,147 |  |  |
Balance at the end of the period at Dec. 31, 2018 | $ 350,727 | $ 51 | $ 1,288,137 | $ 1,462 | $ (938,923)
Common stock, authorized shares (in shares) | 125,000,000 |  |  |  |

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