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Fair value of financial instruments and investments - Narrative (Details) | 12 Months Ended |  |  |
--- | --- | --- | --- | ---
Dec. 31, 2018 USD ($) $ / shares | Aug. 23, 2018 USD ($) | Dec. 31, 2017 USD ($) $ / shares | Aug. 31, 2015 USD ($)
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Marketable securities | $ 58,088,000 |  | $ 79,454,000 |
Deferred consideration payable- long-term | 18,300,000 |  | 0 |
Contingent consideration payable | 310,240,000 |  | 0 |
Deferred consideration payable- current | 19,400,000 |  | 0 |
3.00% Convertible senior notes due 2022 | Convertible debt |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Principal | 150,000,000 |  | 150,000,000 | $ 150,000,000
Interest rate |  |  |  | 3.00%
Debt instrument | 146,600,000 |  | 115,700,000 |
Warrants |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value | $ 0 |  | $ 1,000 |
Warrants | Minimum |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Alternative Investment, Measurement Input | $ / shares | 128.00 |  | 128.00 |
Warrants | Maximum |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Alternative Investment, Measurement Input | $ / shares | 2,520.00 |  | 2,520.00 |
Warrants | Volatility | Minimum |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Alternative Investment, Measurement Input | 0.59 |  | 0.69 |
Warrants | Volatility | Maximum |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Alternative Investment, Measurement Input | 0.60 |  | 0.69 |
Warrants | Risk free interest rate | Minimum |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Alternative Investment, Measurement Input | 0.03 |  | 0.02 |
Warrants | Risk free interest rate | Maximum |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Alternative Investment, Measurement Input | 0.03 |  | 0.02 |
Warrants | Expected life | Minimum |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Alternative Investment, Measurement Input | 0.59 |  | 1.59 |
Warrants | Expected life | Maximum |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Alternative Investment, Measurement Input | 0.72 |  | 1.70 |
Stock Appreciation Rights (SARs) |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value | $ 3,814,000 |  | $ 1,665,000 |
Stock Appreciation Rights (SARs) | Minimum |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Alternative Investment, Measurement Input | $ / shares | 6.76 |  | 6.76 |
Stock Appreciation Rights (SARs) | Maximum |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Alternative Investment, Measurement Input | $ / shares | 30.86 |  | 30.86 |
Stock Appreciation Rights (SARs) | Volatility | Minimum |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Alternative Investment, Measurement Input | 0.47 |  | 0.31 |
Stock Appreciation Rights (SARs) | Volatility | Maximum |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Alternative Investment, Measurement Input | 0.60 |  | 0.70 |
Stock Appreciation Rights (SARs) | Risk free interest rate | Minimum |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Alternative Investment, Measurement Input | 0.02 |  | 0.01 |
Stock Appreciation Rights (SARs) | Risk free interest rate | Maximum |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Alternative Investment, Measurement Input | 0.03 |  | 0.02 |
Stock Appreciation Rights (SARs) | Expected life | Minimum |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Alternative Investment, Measurement Input | 0.01 |  | 0.00 |
Stock Appreciation Rights (SARs) | Expected life | Maximum |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Alternative Investment, Measurement Input | 1.01 |  | 2.00 |
Common stock | Warrants | Fair value of common stock |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Alternative Investment, Measurement Input | $ / shares | 34.32 |  | 16.68 |
Common stock | Stock Appreciation Rights (SARs) | Fair value of common stock |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Alternative Investment, Measurement Input | $ / shares | 34.32 |  | 16.68 |
Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 2 |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Marketable securities | $ 58,088,000 |  | $ 79,454,000 |
Deferred consideration payable | 37,700,000 |  |  |
Warrant liability | 0 |  | 0 |
Stock appreciation rights liability | 0 |  | 0 |
Contingent consideration payable | 0 |  |  |
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value | 0 |  |  |
Agilis |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Development milestone payment obligations | $ 40,000,000 | $ 40,000,000 |  |
Deferred consideration payable |  | 38,100,000 |  |
Agilis | Minimum |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Percentage of annual net sales | 200.00% |  |  |
Agilis | Maximum |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Development milestone payment obligations | $ 60,000,000.0 |  |  |
Priority review voucher amount | 535,000,000.0 |  |  |
Net sales milestones | $ 150,000,000 |  |  |
Percentage of annual net sales | 600.00% |  |  |
Non-collaborative Arrangement Transactions | Agilis |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Development milestone payment obligations | $ 40,000,000 | $ 40,000,000 |  |
Total | Fair Value, Measurements, Recurring |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |
Marketable securities | 58,088,000 |  | 79,454,000 |
Deferred consideration payable | 37,700,000 |  |  |
Warrant liability | 0 |  | 1,000 |
Stock appreciation rights liability | 3,814,000 |  | $ 1,665,000 |
Contingent consideration payable | 257,040,000 |  |  |
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value | $ 53,200,000 |  |  |

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