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Selected quarterly financial data (Details) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 12 Months Ended
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Dec. 31, 2018 | Sep. 30, 2018 | Jun. 30, 2018 | Mar. 31, 2018 | Dec. 31, 2017 | Sep. 30, 2017 | Jun. 30, 2017 | Mar. 31, 2017 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Quarterly Financial Information Disclosure [Abstract] |  |  |  |  |  |  |  |  |  |  |
Net product revenue | $ 85,833 | $ 53,021 | $ 68,170 | $ 55,981 | $ 57,953 | $ 41,780 | $ 47,891 | $ 26,442 | $ 264,734 | $ 194,392 | $ 82,705
Collaboration and grant revenue | 505 | 570 | 573 | 81 | 20,077 | 73 | 71 | 105 |  |  |
Operating expenses | 131,476 | 101,821 | 74,317 | 72,805 | 72,578 | 72,745 | 60,459 | 52,902 | 380,419 | 258,684 | 214,763
Loss from operations | (45,138) | (48,230) | (5,574) | (16,743) | 5,452 | (30,892) | (12,497) | (26,355) | (115,685) | (64,292) | (132,058)
Net loss attributable to common stockholders | $ (48,330) | $ (50,969) | $ (9,520) | $ (19,263) | $ 1,270 | $ (33,738) | $ (17,475) | $ (29,057) | $ (128,081) | $ (79,000) | $ (142,110)
Net loss per share—basic and diluted (in dollars per share) | $ (0.96) | $ (1.06) | $ (0.21) | $ (0.46) | $ 0.03 | $ (0.82) | $ (0.44) | $ (0.85) | $ (2.75) | $ (2.02) | $ (4.17)

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