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Summary of significant accounting policies - Narrative (Details) | 1 Months Ended | 3 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | ---
Aug. 31, 2014 | Dec. 31, 2018 USD ($) | Sep. 30, 2018 USD ($) | Jun. 30, 2018 USD ($) | Mar. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Sep. 30, 2017 USD ($) | Jun. 30, 2017 USD ($) | Mar. 31, 2017 USD ($) | Dec. 31, 2018 USD ($) segment | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Aug. 23, 2018 USD ($) | Jan. 01, 2018 USD ($)
Segment and geographic information |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of operating segments | segment |  |  |  |  |  |  |  |  |  | 1 |  |  |  |
Number of Reporting Units | segment |  |  |  |  |  |  |  |  |  | 1 |  |  |  |
Minimum age of ambulatory patient | 5 years |  |  |  |  |  |  |  |  |  |  |  |  |
Allowance for doubtful accounts |  | $ 700,000 |  |  |  | $ 800,000 |  |  |  | $ 700,000 | $ 800,000 |  |  |
Deferred research and development advance payments |  | 2,400,000 |  |  |  | 500,000 |  |  |  | 2,400,000 | $ 500,000 |  |  |
Impairment of long-lived assets |  |  |  |  |  |  |  |  |  | $ 0 |  |  |  |
Summary |  |  |  |  |  |  |  |  |  |  |  |  |  |
Federal income tax provision at statutory rate |  |  |  |  |  |  |  |  |  | 21.00% | 34.00% | 34.00% |  |
Income tax benefit (expense) |  |  |  |  |  |  |  |  |  | $ 29,000 | $ (1,335,000) | $ (569,000) |  |
Renewal Of Marketing Authorization, Period |  |  |  |  |  |  |  |  |  | 1 year |  |  |  |
Net product revenue |  | 85,833,000 | $ 53,021,000 | $ 68,170,000 | $ 55,981,000 | 57,953,000 | $ 41,780,000 | $ 47,891,000 | $ 26,442,000 | $ 264,734,000 | 194,392,000 | 82,705,000 |  |
Accumulated deficit |  | (938,923,000) |  |  |  | $ (814,108,000) |  |  |  | (938,923,000) | (814,108,000) |  |  |
Contract with Customer, Liability, Cumulative Catch-up Adjustment to Revenue, Change in Measure of Progress |  |  |  |  |  |  |  |  |  | 3,937,000 |  |  |  |
Translarna |  |  |  |  |  |  |  |  |  |  |  |  |  |
Summary |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net product revenue |  |  |  |  |  |  |  |  |  | 171,000,000 | 145,200,000 | $ 81,400,000 |  |
Emflaza |  |  |  |  |  |  |  |  |  |  |  |  |  |
Summary |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net product revenue |  |  |  |  |  |  |  |  |  | 92,000,000 | $ 28,800,000 |  |  |
Agilis |  |  |  |  |  |  |  |  |  |  |  |  |  |
Summary |  |  |  |  |  |  |  |  |  |  |  |  |  |
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Deferred Tax Liabilities |  | $ 122,032,000 |  |  |  |  |  |  |  | 122,032,000 |  |  | $ 115,200,000 |
Difference between Revenue Guidance in Effect before and after Topic 606 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Summary |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative Effect Of New Accounting Principle In Period Of Adoption, Variable Consideration |  |  |  |  |  |  |  |  |  | 600,000 |  |  |  |
Accumulated deficit |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 3,300,000
Minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |
Summary |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative Effect Of New Accounting Principle In Period Of Adoption, Variable Consideration |  |  |  |  |  |  |  |  |  | 10 |  |  |  |
Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |
Summary |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative Effect Of New Accounting Principle In Period Of Adoption, Variable Consideration |  |  |  |  |  |  |  |  |  | $ 15 |  |  |  |

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