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Commitments and contingencies - Narrative (Details) | 12 Months Ended |  |
--- | --- | --- | ---
Dec. 31, 2018 USD ($) operating_lease | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Aug. 23, 2018 USD ($) | Jun. 30, 2016 USD ($)
Other contingencies |  |  |  |  |
Number of Operating Leases | operating_lease | 3 |  |  |  |
Operating Lease, Expense | $ 2,700,000 | $ 2,200,000 | $ 2,200,000 |  |
Akcea |  |  |  |  |
Other contingencies |  |  |  |  |
Development And Regulatory Milestone Payment Obligations, Period | 30 days |  |  |  |
Upfront licensing fee | $ 12,000,000 |  |  |  |
Milestone, Potential Achievements, Regulatory Approval | 4,000,000 |  |  |  |
Funding agreement | Wellcome trust limited |  |  |  |  |
Other contingencies |  |  |  |  |
Development milestone payment obligations | 22,400,000 |  |  |  | $ 800,000
Non-collaborative Arrangement Transactions | Akcea |  |  |  |  |
Other contingencies |  |  |  |  |
Development milestone payment obligations | 6,000,000 |  |  |  |
Agilis |  |  |  |  |
Other contingencies |  |  |  |  |
Development milestone payment obligations | 40,000,000 |  |  | $ 40,000,000 |
Agilis | Non-collaborative Arrangement Transactions |  |  |  |  |
Other contingencies |  |  |  |  |
Development milestone payment obligations | 40,000,000 |  |  | $ 40,000,000 |
Maximum | Akcea |  |  |  |  |
Other contingencies |  |  |  |  |
Milestone, Potential Achievements, Regulatory Approval | 8,000,000 |  |  |  |
Maximum | Agilis |  |  |  |  |
Other contingencies |  |  |  |  |
Development milestone payment obligations | $ 60,000,000.0 |  |  |  |

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- Definition Amount of operating lease expense. Excludes sublease income. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 842 -SubTopic 20 -Section 45 -Paragraph 4 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=77888419&loc=SL77918638-209977 + Details
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