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Consolidated Statements of Operations - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Operating expenses:      
Cost of product sales, excluding amortization of acquired intangible asset $ 12,670 $ 4,577 $ 0
Amortization of acquired intangible asset 22,877 15,380 0
Research and development 171,984 117,456 117,633
Selling, general and administrative 153,548 121,271 97,130
Change in the fair value of deferred and contingent consideration 19,340 0 0
Total operating expenses 380,419 258,684 214,763
Loss from operations (115,685) (64,292) (132,058)
Interest expense, net (12,554) (12,094) (8,276)
Other income (expense), net 129 (1,279) (1,207)
Loss before income tax expense (128,110) (77,665) (141,541)
Income tax benefit (expense) 29 (1,335) (569)
Net loss attributable to common stockholders $ (128,081) $ (79,000) $ (142,110)
Weighted-average shares outstanding:      
Basic and diluted (in shares) 46,576,313 39,183,073 34,044,584
Net loss per share—basic and diluted (in dollars per share) $ (2.75) $ (2.02) $ (4.17)
Net product revenue $ 264,734 $ 194,392 $ 82,705
Net product revenue      
Weighted-average shares outstanding:      
Net product revenue 263,005 174,066 81,447
Collaboration and grant revenue      
Weighted-average shares outstanding:      
Net product revenue $ 1,729 $ 20,326 $ 1,258