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Income taxes (Tables)

12 Months Ended

Dec. 31, 2018

Income Tax Disclosure [Abstract]

Schedule of Income before Income Tax, Domestic and Foreign

The loss from operations before tax (expense) benefit consisted of the following for the years ended December 31, 2018, 2017, and 2016:

		2018			2017			2016
Domestic		(68,461	)		(54,588	)		(61,446	)
Foreign		(59,649	)		(23,077	)		(80,095	)
Total		(128,110	)		(77,665	)		(141,541	)

Components of Income Tax Provision

The Income Tax Provision consisted of the following for the years ended December 31, 2018, 2017 and 2016:

		2018				2017				2016
Current:
U.S. Federal		$	—			$	—			$	—
U.S. State and Local		(38		)		(6		)		(2		)
Foreign		(669		)		(1,131		)		(766		)
Deferred:
U.S. Federal		—				(198		)		199
U.S. State and Local		—				—				—
Foreign		736				—				—
Total tax benefit (expense)		$	29			$	(1,335	)		$	(569	)

Schedule of reconciliation of the U.S. statutory income tax rate to the Company's effective tax rate

A reconciliation of the U.S. statutory income tax rate to the Company’s effective tax rate is as follows:

		December 31,
		2018			2017			2016
Federal income tax provision at statutory rate		21.00	%		34.00	%		34.00	%
State income tax provision, net of federal benefit		0.05			(1.01	)		3.05
Permanent differences		(6.41	)		(8.48	)		(3.70	)
Research and development		6.49			19.53			16.66
Change in valuation allowances		2.20			29.10			(30.72	)
Change in deferred tax assets		(14.22	)		(64.12	)		—
Foreign tax rate differential		(9.10	)		(10.33	)		(19.84	)
Benefit allocated from other comprehensive income		—			(0.26	)		0.14
Other		0.01			(0.15	)		0.01
Effective income tax rate		0.02	%		(1.72	)%		(0.40	)%

Schedule of significant components of the Company's deferred tax assets and liabilities

The significant components of the Company’s deferred tax assets and liabilities at December 31, 2018 and 2017 are as follows:

		2018				2017
Deferred tax assets:
Accrued expense		$	714			$	625
Amortization		5,148				2,116
Depreciation		1,601				1,749
Federal tax credits		89,070				80,961
State tax credits		5,473				7,148
Federal net operating losses		62,159				61,068
State net operating losses		165				11,884
Foreign net operating losses		736				—
Capitalized research and development costs		2,093				3,332
Share based compensation and other		21,411				18,815
Total gross deferred tax assets		188,570				187,698
Less valuation allowance		(180,481		)		(177,631		)
Total deferred tax assets, net of valuation allowance		$	8,089			$	10,067
Deferred tax liabilities:
Convertible debt		$	(7,353	)		$	(9,927	)
OCI unrealized (gains)/losses		—				(140		)
Indefinite lived intangible		(122,032		)		—
Total gross deferred tax liabilities		(129,385		)		(10,067		)
Net deferred tax assets (liabilities)		$	(121,296	)		$	—

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Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years.

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

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Tabular disclosure of income before income tax between domestic and foreign jurisdictions.

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