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The Company (Details) $ in Thousands			1 Months Ended
	Aug. 23, 2018 USD ($) shares	Apr. 20, 2017 USD ($) shares	Aug. 31, 2014	Dec. 31, 2018 USD ($) country	Dec. 31, 2017 USD ($)	Aug. 31, 2015
Minimum age of ambulatory patient			5 years
Accumulated deficit				$ (938,923)	$ (814,108)
3.00% Convertible senior notes due 2022 | Convertible debt
Interest rate						3.00%
Marathon Pharmaceuticals, LLC | Non-collaborative Arrangement Transactions
Cash consideration		$ 75,000
Equity interest issued or issuable, number of shares (in shares) | shares		6,683,598
Numerator for calculation of number of shares of equity interests issued to acquire entity		$ 65,000
Trading day period		15 days
Development milestone payment obligations		$ 50,000
Translarna
Number of countries (over) | country				40
Agilis
Cash consideration	$ 49,221
Equity interest issued or issuable, number of shares (in shares) | shares	3,500,907
Numerator for calculation of number of shares of equity interests issued to acquire entity	$ 150,000
Trading day period	10 days
Development milestone payment obligations	$ 40,000			$ 40,000
Agilis | Non-collaborative Arrangement Transactions
Development milestone payment obligations	$ 40,000			$ 40,000

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