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Acquisitions - Narrative (Details) - USD ($)			4 Months Ended	12 Months Ended
	Aug. 23, 2018	Apr. 20, 2017	Dec. 31, 2018	Dec. 31, 2018	Dec. 31, 2017
Finite-Lived Intangible Assets [Line Items]
Contingent consideration payable			$ 310,240,000	$ 310,240,000	$ 0
Issuance of common stock related to acquisition				$ 155,860,000	75,191,000
Useful life				7 years
Intellectual Property | Marathon Pharmaceuticals, LLC
Finite-Lived Intangible Assets [Line Items]
Cash consideration		$ 75,000,000
Issuance of common stock related to acquisition (in shares)		6,683,598		6,683,598
Issuance of common stock related to acquisition		$ 75,200,000
Acquisition costs		$ 2,200,000
Useful life		7 years
Non-collaborative Arrangement Transactions | Marathon Pharmaceuticals, LLC
Finite-Lived Intangible Assets [Line Items]
Cash consideration		$ 75,000,000
Equity interest issued or issuable, number of shares (in shares)		6,683,598
Numerator for calculation of number of shares of equity interests issued to acquire entity		$ 65,000,000
Trading day period		15 days
Development milestone payment obligations		$ 50,000,000
Agilis
Finite-Lived Intangible Assets [Line Items]
Cash consideration	$ 49,221,000
Equity interest issued or issuable, number of shares (in shares)	3,500,907
Fair value of PTC common stock issued	$ 155,860,000
Estimated fair value of contingent consideration payable	290,500,000
Deferred consideration payable	38,100,000
Business combination, consideration	533,681,000
Acquisition Related Costs				$ 1,700,000
Net loss attributable to common stockholders				$ (138,083,000)	$ (93,333,000)
Issuance of common stock related to acquisition (in shares)				3,500,907
Numerator for calculation of number of shares of equity interests issued to acquire entity	$ 150,000,000
Trading day period	10 days
Earnings (loss) of acquire since acquisition date			(8,700,000)
Development milestone payment obligations	$ 40,000,000		40,000,000	$ 40,000,000
Agilis | Non-collaborative Arrangement Transactions
Finite-Lived Intangible Assets [Line Items]
Development milestone payment obligations	$ 40,000,000		40,000,000	40,000,000
Acquisition-related Costs | Agilis
Finite-Lived Intangible Assets [Line Items]
Net loss attributable to common stockholders				1,700,000
Maximum | Agilis
Finite-Lived Intangible Assets [Line Items]
Priority review voucher amount				535,000,000.0
Net sales milestones			$ 150,000,000	$ 150,000,000
Percentage of annual net sales			600.00%	600.00%
Development milestone payment obligations			$ 60,000,000.0	$ 60,000,000.0
Minimum | Agilis
Finite-Lived Intangible Assets [Line Items]
Percentage of annual net sales			200.00%	200.00%

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