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Acquisitions - Preliminary Allocation of purchase price (Details) - USD ($)
$ in Thousands
 3 Months Ended 12 Months Ended
Dec. 31, 2018
Dec. 31, 2018
Aug. 23, 2018
Dec. 31, 2017
Finite-Lived Intangible Assets [Line Items]        
Indefinite-lived Intangible Assets Acquired   $ 576,500    
Goodwill $ 82,341 82,341   $ 0
Goodwill Adjustment 18,000      
Agilis        
Finite-Lived Intangible Assets [Line Items]        
Cash and cash equivalents 328 328 $ 328  
Prepaid expenses and other current assets 181 181 181  
Fixed assets 153 153 153  
Other assets 38 38 38  
Intangible assets - IPR&D     480,000  
Intangible assets - in process research and development (“IPRD”) Adjustment 96,500      
Accounts payable and accrued expenses (3,828) (3,828) (3,828)  
Deferred tax liability (122,032) (122,032) (115,200)  
Deferred tax liability adjustment (6,832)      
Fair value of net assets acquired 451,340 451,340 361,672  
Fair value of net assets acquired adjustment 89,668      
Goodwill     100,309  
Goodwill Adjustment (17,968)      
Total purchase price 533,681 $ 533,681 $ 461,981  
Total purchase price adjustment $ 71,700