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Acquisitions -Schedule of Business Acquisitions (Details) - Agilis $ in Thousands	12 Months Ended
	Dec. 31, 2018 USD ($)
Significant unobservable inputs (level 3)
Changes in the fair value of warrant liability
Ending balance	$ 53,200
Liability, Development and Regulatory Milestone
Changes in the fair value of warrant liability
Ending balance	257,040
Liability, Development and Regulatory Milestone | Significant unobservable inputs (level 3)
Changes in the fair value of warrant liability
Change in fair value	6,460
Additions	263,500
Payments	0
Ending balance	257,040
Liability, Net Sales Milestones and Royalties
Changes in the fair value of warrant liability
Ending balance	53,200
Liability, Net Sales Milestones and Royalties | Significant unobservable inputs (level 3)
Changes in the fair value of warrant liability
Beginning balance	0
Change in fair value	(26,200)
Additions	27,000
Payments	0
Ending balance	$ 53,200

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+ References

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Amount of gain (loss) recognized on the income statement for financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

+ References

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- Definition

Amount of purchases, (sales), issuances and (settlements) of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

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