Business Combination, Consideration, Liability, Deferred Consideration Payable

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- Definition

Business Combination, Consideration, Liability, Deferred Consideration Payable- Current

+ References

No definition available.

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- Definition

Business Combination, Consideration, Liability, Deferred Consideration Payable, Long Term

+ References

No definition available.

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- Definition

Contingent Liability, Milestone, Potential Achievements, Net Sales Milestone

+ References

No definition available.

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- Definition

Contingent Liability, Milestone, Potential Achievements, Priority Review Voucher Amount

+ References

No definition available.

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- Definition

Contingent Liability, Milestone, Potential Achievements, Product Sales Percentage

+ References

No definition available.

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- Definition

Represents the development milestones payments which the entity is obligated to pay under certain contractual agreements.

+ References

No definition available.

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- Definition

Represents the amount of outstanding stock appreciation rights liability.

+ References

No definition available.

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- Definition

Value of input used to measure alternative investment.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (bbb)(2)
-URI http://asc.fasb.org/extlink&oid=99377789&loc=d3e19207-110258

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- Definition

Amount of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 320
-SubTopic 10
-Section 45
-Paragraph 1
-Subparagraph (b)
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- Definition

Amount of liability recognized arising from contingent consideration in a business combination, expected to be settled beyond one year or the normal operating cycle, if longer.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 805
-SubTopic 30
-Section 25
-Paragraph 6
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-Topic 805
-SubTopic 30
-Section 35
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-Subparagraph b
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- Definition

Face (par) amount of debt instrument at time of issuance.

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Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 835
-SubTopic 30
-Section 45
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-SubTopic 30
-Section 55
-Paragraph 8
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- Definition

Fair value portion of debt instrument payable, including, but not limited to, notes payable and loans payable.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 825
-SubTopic 10
-Section 50
-Paragraph 10
-URI http://asc.fasb.org/extlink&oid=109250915&loc=d3e13433-108611

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- Definition

Contractual interest rate for funds borrowed, under the debt agreement.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02.22(a)(1))
-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

No definition available.

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- Definition

Fair value of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)
-URI http://asc.fasb.org/extlink&oid=99377789&loc=d3e19207-110258

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- Definition

Value of outstanding derivative securities that permit the holder the right to purchase securities (usually equity) from the issuer at a specified price.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08.(i))
-URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690

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Fair value of financial instruments and investments - Narrative (Details)	12 Months Ended
	Dec. 31, 2018 USD ($) $ / shares	Aug. 23, 2018 USD ($)	Dec. 31, 2017 USD ($) $ / shares	Aug. 31, 2015 USD ($)
Financial assets and liabilities measured at fair value on recurring basis
Marketable securities	$ 58,088,000		$ 79,454,000
Deferred consideration payable- long-term	18,300,000		0
Contingent consideration payable	310,240,000		0
Deferred consideration payable- current	19,400,000		0
3.00% Convertible senior notes due 2022 \| Convertible debt
Financial assets and liabilities measured at fair value on recurring basis
Principal	150,000,000		150,000,000	$ 150,000,000
Interest rate				3.00%
Debt instrument	146,600,000		115,700,000
Warrants
Financial assets and liabilities measured at fair value on recurring basis
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value	$ 0		$ 1,000
Warrants \| Minimum
Financial assets and liabilities measured at fair value on recurring basis
Alternative Investment, Measurement Input \| $ / shares	128.00		128.00
Warrants \| Maximum
Financial assets and liabilities measured at fair value on recurring basis
Alternative Investment, Measurement Input \| $ / shares	2,520.00		2,520.00
Warrants \| Volatility \| Minimum
Financial assets and liabilities measured at fair value on recurring basis
Alternative Investment, Measurement Input	0.59		0.69
Warrants \| Volatility \| Maximum
Financial assets and liabilities measured at fair value on recurring basis
Alternative Investment, Measurement Input	0.60		0.69
Warrants \| Risk free interest rate \| Minimum
Financial assets and liabilities measured at fair value on recurring basis
Alternative Investment, Measurement Input	0.03		0.02
Warrants \| Risk free interest rate \| Maximum
Financial assets and liabilities measured at fair value on recurring basis
Alternative Investment, Measurement Input	0.03		0.02
Warrants \| Expected life \| Minimum
Financial assets and liabilities measured at fair value on recurring basis
Alternative Investment, Measurement Input	0.59		1.59
Warrants \| Expected life \| Maximum
Financial assets and liabilities measured at fair value on recurring basis
Alternative Investment, Measurement Input	0.72		1.70
Stock Appreciation Rights (SARs)
Financial assets and liabilities measured at fair value on recurring basis
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value	$ 3,814,000		$ 1,665,000
Stock Appreciation Rights (SARs) \| Minimum
Financial assets and liabilities measured at fair value on recurring basis
Alternative Investment, Measurement Input \| $ / shares	6.76		6.76
Stock Appreciation Rights (SARs) \| Maximum
Financial assets and liabilities measured at fair value on recurring basis
Alternative Investment, Measurement Input \| $ / shares	30.86		30.86
Stock Appreciation Rights (SARs) \| Volatility \| Minimum
Financial assets and liabilities measured at fair value on recurring basis
Alternative Investment, Measurement Input	0.47		0.31
Stock Appreciation Rights (SARs) \| Volatility \| Maximum
Financial assets and liabilities measured at fair value on recurring basis
Alternative Investment, Measurement Input	0.60		0.70
Stock Appreciation Rights (SARs) \| Risk free interest rate \| Minimum
Financial assets and liabilities measured at fair value on recurring basis
Alternative Investment, Measurement Input	0.02		0.01
Stock Appreciation Rights (SARs) \| Risk free interest rate \| Maximum
Financial assets and liabilities measured at fair value on recurring basis
Alternative Investment, Measurement Input	0.03		0.02
Stock Appreciation Rights (SARs) \| Expected life \| Minimum
Financial assets and liabilities measured at fair value on recurring basis
Alternative Investment, Measurement Input	0.01		0.00
Stock Appreciation Rights (SARs) \| Expected life \| Maximum
Financial assets and liabilities measured at fair value on recurring basis
Alternative Investment, Measurement Input	1.01		2.00
Common stock \| Warrants \| Fair value of common stock
Financial assets and liabilities measured at fair value on recurring basis
Alternative Investment, Measurement Input \| $ / shares	34.32		16.68
Common stock \| Stock Appreciation Rights (SARs) \| Fair value of common stock
Financial assets and liabilities measured at fair value on recurring basis
Alternative Investment, Measurement Input \| $ / shares	34.32		16.68
Fair Value, Measurements, Recurring \| Fair Value, Inputs, Level 2
Financial assets and liabilities measured at fair value on recurring basis
Marketable securities	$ 58,088,000		$ 79,454,000
Deferred consideration payable	37,700,000
Warrant liability	0		0
Stock appreciation rights liability	0		0
Contingent consideration payable	0
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value	0
Agilis
Financial assets and liabilities measured at fair value on recurring basis
Development milestone payment obligations	$ 40,000,000	$ 40,000,000
Deferred consideration payable		38,100,000
Agilis \| Minimum
Financial assets and liabilities measured at fair value on recurring basis
Percentage of annual net sales	200.00%
Agilis \| Maximum
Financial assets and liabilities measured at fair value on recurring basis
Development milestone payment obligations	$ 60,000,000.0
Priority review voucher amount	535,000,000.0
Net sales milestones	$ 150,000,000
Percentage of annual net sales	600.00%
Non-collaborative Arrangement Transactions \| Agilis
Financial assets and liabilities measured at fair value on recurring basis
Development milestone payment obligations	$ 40,000,000	$ 40,000,000
Total \| Fair Value, Measurements, Recurring
Financial assets and liabilities measured at fair value on recurring basis
Marketable securities	58,088,000		79,454,000
Deferred consideration payable	37,700,000
Warrant liability	0		1,000
Stock appreciation rights liability	3,814,000		$ 1,665,000
Contingent consideration payable	257,040,000
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value	$ 53,200,000