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Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Total
Common stock
Additional paid-in capital
Accumulated other comprehensive (loss) income
Accumulated deficit
Balance (in shares) at Dec. 31, 2015   33,916,559      
Balance at the beginning of the period at Dec. 31, 2015 $ 226,001 $ 34 $ 820,165 $ (1,200) $ (592,998)
Increase (Decrease) in Stockholders' Equity          
Exercise of options (in shares)   89,216      
Exercise of options 968 $ 0 968    
Restricted stock vesting and issuance (in shares)   163,635      
Restricted stock vesting and issuance 0        
Share-based compensation expense 35,009   35,009    
Net loss (142,110)       (142,110)
Comprehensive loss (285)     (285)  
Balance (in shares) at Dec. 31, 2016   34,169,410      
Balance at the end of the period at Dec. 31, 2016 119,583 $ 34 856,142 (1,485) (735,108)
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock related to acquisition (in shares)   6,683,598      
Issuance of common stock related to acquisition 75,191 $ 7 75,184    
Exercise of options (in shares)   202,085      
Exercise of options 2,182 $ 0 2,182    
Restricted stock vesting and issuance (in shares)   287,531      
Restricted stock vesting and issuance 1 $ 1      
Issuance of common stock in connection with an employee stock purchase plan (in shares)   269,771      
Issuance of common stock in connection with an employee stock purchase plan 2,467   2,467    
Share-based compensation expense 30,559   30,559    
Net loss (79,000)       (79,000)
Comprehensive loss 5,454     5,454  
Balance (in shares) at Dec. 31, 2017   41,612,395      
Balance at the end of the period at Dec. 31, 2017 $ 156,437 $ 42 966,534 3,969 (814,108)
Common stock, authorized shares (in shares) 125,000,000        
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock related to acquisition $ 155,860 $ 3 155,857    
Issuance of common stock related to equity offering (in shares)   4,600,000      
Issuance of common stock related to equity offering 117,916 $ 5 117,911    
Exercise of options (in shares)   633,973      
Exercise of options 10,868 $ 1 10,867    
Restricted stock vesting and issuance (in shares)   119,691      
Restricted stock vesting and issuance 0 $ 0      
Issuance of common stock in connection with an employee stock purchase plan (in shares)   139,181      
Issuance of common stock in connection with an employee stock purchase plan 2,787 $ 0 2,787    
Share-based compensation expense 33,252   33,252    
Receivable from investor 929   929    
Net loss (128,081)       (128,081)
Comprehensive loss (2,507)     (2,507)  
Balance (in shares) at Dec. 31, 2018   50,606,147      
Balance at the end of the period at Dec. 31, 2018 $ 350,727 $ 51 $ 1,288,137 $ 1,462 $ (938,923)
Common stock, authorized shares (in shares) 125,000,000