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Fair value of financial instruments and investments - Fair Value Liabilities Measured (Details)	Dec. 31, 2018 USD ($) $ / shares	Dec. 31, 2017 USD ($) $ / shares	Dec. 31, 2016 USD ($)
Warrants
Fair value of warrant liability
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value	$ 0	$ 1,000
Stock Appreciation Rights (SARs)
Fair value of warrant liability
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value	$ 3,814,000	$ 1,665,000
Minimum | Warrants
Fair value of warrant liability
Alternative Investment, Measurement Input | $ / shares	128.00	128.00
Minimum | Stock Appreciation Rights (SARs)
Fair value of warrant liability
Alternative Investment, Measurement Input | $ / shares	6.76	6.76
Minimum | Volatility | Warrants
Fair value of warrant liability
Alternative Investment, Measurement Input	0.59	0.69
Minimum | Volatility | Stock Appreciation Rights (SARs)
Fair value of warrant liability
Alternative Investment, Measurement Input	0.47	0.31
Minimum | Risk free interest rate | Warrants
Fair value of warrant liability
Alternative Investment, Measurement Input	0.03	0.02
Minimum | Risk free interest rate | Stock Appreciation Rights (SARs)
Fair value of warrant liability
Alternative Investment, Measurement Input	0.02	0.01
Minimum | Expected life | Warrants
Fair value of warrant liability
Alternative Investment, Measurement Input	0.59	1.59
Minimum | Expected life | Stock Appreciation Rights (SARs)
Fair value of warrant liability
Alternative Investment, Measurement Input	0.01	0.00
Maximum | Warrants
Fair value of warrant liability
Alternative Investment, Measurement Input | $ / shares	2,520.00	2,520.00
Maximum | Stock Appreciation Rights (SARs)
Fair value of warrant liability
Alternative Investment, Measurement Input | $ / shares	30.86	30.86
Maximum | Volatility | Warrants
Fair value of warrant liability
Alternative Investment, Measurement Input	0.60	0.69
Maximum | Volatility | Stock Appreciation Rights (SARs)
Fair value of warrant liability
Alternative Investment, Measurement Input	0.60	0.70
Maximum | Risk free interest rate | Warrants
Fair value of warrant liability
Alternative Investment, Measurement Input	0.03	0.02
Maximum | Risk free interest rate | Stock Appreciation Rights (SARs)
Fair value of warrant liability
Alternative Investment, Measurement Input	0.03	0.02
Maximum | Expected life | Warrants
Fair value of warrant liability
Alternative Investment, Measurement Input	0.72	1.70
Maximum | Expected life | Stock Appreciation Rights (SARs)
Fair value of warrant liability
Alternative Investment, Measurement Input	1.01	2.00
Common stock | Fair value of common stock | Warrants
Fair value of warrant liability
Alternative Investment, Measurement Input | $ / shares	34.32	16.68
Common stock | Fair value of common stock | Stock Appreciation Rights (SARs)
Fair value of warrant liability
Alternative Investment, Measurement Input | $ / shares	34.32	16.68
Significant unobservable inputs (level 3) | Warrants
Fair value of warrant liability
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value	$ 0	$ 1,000	$ 1,000
Significant unobservable inputs (level 3) | Stock Appreciation Rights (SARs)
Fair value of warrant liability
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value	3,814,000	1,665,000	$ 865,000
Significant unobservable inputs (level 3) | Agilis
Fair value of warrant liability
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value	$ 53,200,000
Liability, Net Sales Milestones and Royalties | Minimum | Probabilities of success | Commitments [Member]
Fair value of warrant liability
Alternative Investment, Measurement Input	0.25
Liability, Net Sales Milestones and Royalties | Maximum | Probabilities of success | Commitments [Member]
Fair value of warrant liability
Alternative Investment, Measurement Input	0.89
Liability, Net Sales Milestones and Royalties | Agilis
Fair value of warrant liability
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value	$ 53,200,000
Liability, Net Sales Milestones and Royalties | Agilis | Minimum | Potential net sales milestones | Commitments [Member]
Fair value of warrant liability
Alternative Investment, Measurement Input	0
Liability, Net Sales Milestones and Royalties | Agilis | Minimum | Potential percentage of net sales for royalties | Commitments [Member]
Fair value of warrant liability
Alternative Investment, Measurement Input	0.02
Liability, Net Sales Milestones and Royalties | Agilis | Maximum | Potential net sales milestones | Commitments [Member]
Fair value of warrant liability
Alternative Investment, Measurement Input	150,000,000
Liability, Net Sales Milestones and Royalties | Agilis | Maximum | Potential percentage of net sales for royalties | Commitments [Member]
Fair value of warrant liability
Alternative Investment, Measurement Input	0.06
Liability, Net Sales Milestones and Royalties | Significant unobservable inputs (level 3) | Agilis
Fair value of warrant liability
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value	$ 53,200,000	$ 0
Liability, Development and Regulatory Milestone | Minimum | Probabilities of success | Commitments [Member]
Fair value of warrant liability
Alternative Investment, Measurement Input	0.25
Liability, Development and Regulatory Milestone | Maximum | Probabilities of success | Commitments [Member]
Fair value of warrant liability
Alternative Investment, Measurement Input	0.89
Liability, Development and Regulatory Milestone | Agilis
Fair value of warrant liability
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value	$ 257,040,000
Liability, Development and Regulatory Milestone | Agilis | Minimum | Potential development and regulatory milestones | Commitments [Member]
Fair value of warrant liability
Alternative Investment, Measurement Input	0
Liability, Development and Regulatory Milestone | Agilis | Minimum | Discount rates | Commitments [Member]
Fair value of warrant liability
Alternative Investment, Measurement Input	0.058
Liability, Development and Regulatory Milestone | Agilis | Maximum | Potential development and regulatory milestones | Commitments [Member]
Fair value of warrant liability
Alternative Investment, Measurement Input	555,000,000
Liability, Development and Regulatory Milestone | Agilis | Maximum | Discount rates | Commitments [Member]
Fair value of warrant liability
Alternative Investment, Measurement Input	0.080
Liability, Development and Regulatory Milestone | Significant unobservable inputs (level 3) | Agilis
Fair value of warrant liability
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value	$ 257,040,000

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- Definition

Value of input used to measure alternative investment.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (bbb)(2)
-URI http://asc.fasb.org/extlink&oid=99377789&loc=d3e19207-110258

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+ References

No definition available.

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- Definition

Fair value of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

+ References

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-Topic 820
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-Paragraph 2
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