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Stock award plan - Share-based Compensation (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Share-based compensation expense recorded in the statement of operations
Share-based compensation expense	$ 33,252	$ 30,559	$ 35,009
Research and development
Share-based compensation expense recorded in the statement of operations
Share-based compensation expense	16,096	15,456	16,812
Selling, general and administrative
Share-based compensation expense recorded in the statement of operations
Share-based compensation expense	$ 17,156	$ 15,103	$ 18,197

X

- Definition

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 1
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+ References

No definition available.

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