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Revenue recognition - Income Statement Impacts (Details) - USD ($)
$ in Thousands
 3 Months Ended 12 Months Ended
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Revenues:                      
Net product revenue $ 85,833 $ 53,021 $ 68,170 $ 55,981 $ 57,953 $ 41,780 $ 47,891 $ 26,442 $ 264,734 $ 194,392 $ 82,705
Operating expenses:                      
Amortization of acquired intangible asset                 22,877 15,380 0
Research and development                 171,984 117,456 117,633
Selling, general and administrative                 153,548 121,271 97,130
Change in the fair value of deferred and contingent consideration                 19,340 0 0
Total operating expenses 131,476 101,821 74,317 72,805 72,578 72,745 60,459 52,902 380,419 258,684 214,763
Loss from operations (45,138) (48,230) (5,574) (16,743) 5,452 (30,892) (12,497) (26,355) (115,685) (64,292) (132,058)
Interest expense, net                 (12,554) (12,094) (8,276)
Other income (expense), net                 129 (1,279) (1,207)
Loss before income tax expense                 (128,110) (77,665) (141,541)
Income tax benefit (expense)                 29 (1,335) (569)
Net loss attributable to common stockholders $ (48,330) $ (50,969) $ (9,520) $ (19,263) $ 1,270 $ (33,738) $ (17,475) $ (29,057) (128,081) (79,000) (142,110)
Adjustments | ASU 2014-09                      
Revenues:                      
Net product revenue                 (5,177)    
Operating expenses:                      
Cost of product sales, excluding amortization of acquired intangible asset                 (84)    
Amortization of acquired intangible asset                 0    
Research and development                 0    
Selling, general and administrative                 0    
Change in the fair value of deferred and contingent consideration                 0    
Total operating expenses                 (84)    
Loss from operations                 (5,093)    
Interest expense, net                 0    
Other income (expense), net                 0    
Loss before income tax expense                 (5,093)    
Income tax benefit (expense)                 0    
Net loss attributable to common stockholders                 (5,093)    
Balances without adoption of Topic 606                      
Revenues:                      
Net product revenue                 259,557    
Operating expenses:                      
Cost of product sales, excluding amortization of acquired intangible asset                 12,586    
Amortization of acquired intangible asset                 22,877    
Research and development                 171,984    
Selling, general and administrative                 153,548    
Change in the fair value of deferred and contingent consideration                 19,340    
Total operating expenses                 380,335    
Loss from operations                 (120,778)    
Interest expense, net                 (12,554)    
Other income (expense), net                 129    
Loss before income tax expense                 (133,203)    
Income tax benefit (expense)                 29    
Net loss attributable to common stockholders                 (133,174)    
Net product revenue                      
Revenues:                      
Net product revenue                 263,005 174,066 81,447
Net product revenue | Adjustments | ASU 2014-09                      
Revenues:                      
Net product revenue                 (5,177)    
Net product revenue | Balances without adoption of Topic 606                      
Revenues:                      
Net product revenue                 257,828    
Collaboration and grant revenue                      
Revenues:                      
Net product revenue                 1,729 $ 20,326 $ 1,258
Collaboration and grant revenue | Adjustments | ASU 2014-09                      
Revenues:                      
Net product revenue                 0    
Collaboration and grant revenue | Balances without adoption of Topic 606                      
Revenues:                      
Net product revenue                 $ 1,729