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Income taxes - Tax Rate Reconciliation (Details)	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Reconciliation of the U.S. statutory income tax rate to the entity's effective tax rate
Federal income tax provision at statutory rate	21.00%	34.00%	34.00%
State income tax provision, net of federal benefit	0.05%	(1.01%)	3.05%
Permanent differences	(6.41%)	(8.48%)	(3.70%)
Research and development	6.49%	19.53%	16.66%
Change in valuation allowances	2.20%	29.10%	(30.72%)
Change in deferred tax assets	(14.22%)	(64.12%)	0.00%
Foreign tax rate differential	(9.10%)	(10.33%)	(19.84%)
Benefit allocated from other comprehensive income	0.00%	(0.26%)	0.14%
Other	0.01%	(0.15%)	0.01%
Effective income tax rate	0.02%	(1.72%)	(0.40%)

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to permanent differences.

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Percentage of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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Percentage of domestic federal statutory tax rate applicable to pretax income (loss).

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