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Income taxes - Deferred Tax Assets and Liabilities (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Deferred tax assets:    
Accrued expense $ 714 $ 625
Amortization 5,148 2,116
Depreciation 1,601 1,749
Federal tax credits 89,070 80,961
State tax credits 5,473 7,148
Federal net operating losses 62,159 61,068
State net operating losses 165 11,884
Foreign net operating losses 736 0
Capitalized research and development costs 2,093 3,332
Share based compensation and other 21,411 18,815
Total gross deferred tax assets 188,570 187,698
Less valuation allowance (180,481) (177,631)
Deferred Tax Assets, Net of Valuation Allowance 8,089 10,067
Deferred tax liabilities:    
Convertible debt (7,353) (9,927)
OCI unrealized (gains)/losses 0 (140)
Indefinite lived intangible (122,032) 0
Total gross deferred tax liabilities 129,385 10,067
Deferred Tax Liabilities, Net (121,296) $ 0
Early Stage Collaborations | Research And Development Event Milestones    
Deferred tax liabilities:    
Revenue Recognition, Milestone, Potential Achievements $ 143,000