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Intangible assets and goodwill - Narrative (Details) - USD ($) $ in Thousands	3 Months Ended	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016	Apr. 20, 2017
Finite-Lived Intangible Assets [Line Items]
Useful life		7 years
Amortization of acquired intangible asset		$ 22,877	$ 15,380	$ 0
Total allocation of IPR&D assets		576,500
Goodwill	$ 82,341	82,341	0
Goodwill Adjustment	18,000
Akcea
Finite-Lived Intangible Assets [Line Items]
Upfront licensing fee		$ 12,000
Development And Regulatory Milestone Payment Obligations, Period		30 days
Non-collaborative Arrangement Transactions | Akcea
Finite-Lived Intangible Assets [Line Items]
Development milestone payment obligations	6,000	$ 6,000
Emflaza
Finite-Lived Intangible Assets [Line Items]
Development milestone payment obligations	14,400	14,400
Emflaza asset acquisition
Finite-Lived Intangible Assets [Line Items]
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Finite-Lived Intangibles					$ 148,400
Marathon Pharmaceuticals, LLC
Finite-Lived Intangible Assets [Line Items]
Development milestone payment obligations	6,000	6,000
Intellectual Property
Finite-Lived Intangible Assets [Line Items]
Amortization of acquired intangible asset		22,900	$ 15,400
Finite-Lived Intangible Assets, Accumulated Amortization	$ 38,300	$ 38,300

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