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Intangible assets and goodwill - Future Amortization (Details) - USD ($)
$ in Thousands
Dec. 31, 2018
Sep. 30, 2018
Finite-Lived Intangible Assets [Line Items]    
Total   $ 124,531
Marathon Pharmaceuticals, LLC | Intellectual Property    
Finite-Lived Intangible Assets [Line Items]    
2019 $ 24,283  
2020 24,276  
2021 24,277  
2022 24,277  
2023 and thereafter $ 27,418