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Selected quarterly financial data (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2018	Sep. 30, 2018	Jun. 30, 2018	Mar. 31, 2018	Dec. 31, 2017	Sep. 30, 2017	Jun. 30, 2017	Mar. 31, 2017	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Quarterly Financial Information Disclosure [Abstract]
Net product revenue	$ 85,833	$ 53,021	$ 68,170	$ 55,981	$ 57,953	$ 41,780	$ 47,891	$ 26,442	$ 264,734	$ 194,392	$ 82,705
Collaboration and grant revenue	505	570	573	81	20,077	73	71	105
Operating expenses	131,476	101,821	74,317	72,805	72,578	72,745	60,459	52,902	380,419	258,684	214,763
Loss from operations	(45,138)	(48,230)	(5,574)	(16,743)	5,452	(30,892)	(12,497)	(26,355)	(115,685)	(64,292)	(132,058)
Net loss attributable to common stockholders	$ (48,330)	$ (50,969)	$ (9,520)	$ (19,263)	$ 1,270	$ (33,738)	$ (17,475)	$ (29,057)	$ (128,081)	$ (79,000)	$ (142,110)
Net loss per share—basic and diluted (in dollars per share)	$ (0.96)	$ (1.06)	$ (0.21)	$ (0.46)	$ 0.03	$ (0.82)	$ (0.44)	$ (0.85)	$ (2.75)	$ (2.02)	$ (4.17)

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