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Revenue recognition - Narrative (Details) | 1 Months Ended | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | ---
Oct. 31, 2017 USD ($) | Nov. 30, 2014 USD ($) | Jan. 31, 2014 USD ($) | Aug. 31, 2013 USD ($) | Nov. 30, 2011 USD ($) compound | Mar. 31, 2019 USD ($) segment deliverable | Mar. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) deliverable | Dec. 31, 2018 USD ($)
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Contract with Customer, Liability |  |  |  |  |  | $ 14,350,000 | $ 9,300,000 | $ 11,891,000 | $ 12,938,000
Number of operating segments | segment |  |  |  |  |  | 1 |  |  |
Net product revenue |  |  |  |  |  | $ 53,054,000 | 55,981,000 |  |
Upfront cash payment |  |  |  |  |  | 1,412,000 | 1,346,000 |  |
Revenue |  |  |  |  |  | 53,583,000 | 56,062,000 |  |
Performance obligations satisfied in current period |  |  |  |  |  |  | 55,981,000 |  |
Licensing And Collaboration Agreement |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Upfront cash payment |  |  |  |  | $ 30,000,000 |  |  |  |
Performance obligations satisfied in current period | $ 20,000,000 | $ 10,000,000 | $ 7,500,000 | $ 10,000,000 |  |  |  |  |
Licensing And Collaboration Agreement | Research And Development Event Milestones |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Revenue recognition, milestone, potential achievements |  |  |  |  | 135,000,000 | 87,500,000 |  |  |
Licensing And Collaboration Agreement | Sales Milestones |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Revenue recognition, milestone, potential achievements |  |  |  |  | $ 325,000,000 | 325,000,000 |  |  |
Discovery Agreements |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  | 0 | 0 |  |
Early Stage Collaborations |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  | 0 | 0 |  |
Early Stage Collaborations | Research And Development Event Milestones |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Revenue recognition, milestone, potential achievements |  |  |  |  |  | 143,000,000 |  |  |
Early Stage Collaborations | Sales Milestones |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Revenue recognition, milestone, potential achievements |  |  |  |  |  | 252,000,000 |  |  |
United States |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Net product revenue |  |  |  |  |  | 17,800,000 | 19,200,000 |  |
Non-US |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Net product revenue |  |  |  |  |  | $ 35,300,000 | 36,800,000 |  |
Collaborative Arrangement | Roche And Sma Foundation |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Number of compounds in preclinical development | compound |  |  |  |  | 3 |  |  |  |
Number of significant deliverables | deliverable |  |  |  |  |  |  |  | 2 |
Collaboration And Discovery Agreements |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Number of significant deliverables | deliverable |  |  |  |  |  | 2 |  |  |
Minimum | Collaboration And Discovery Agreements |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Collaborative arrangements research period for applying discovery technology |  |  |  |  |  | 3 years |  |  |
Maximum | Collaboration And Discovery Agreements |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Collaborative arrangements research period for applying discovery technology |  |  |  |  |  | 4 years |  |  |
Roche | Licensing And Collaboration Agreement |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  | $ 100,000 | $ 100,000 |  |

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