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v3.19.1

Fair value of financial instruments and marketable securities - Warrants and SARs (Details) $ in Thousands | 3 Months Ended |
--- | --- | ---
Mar. 31, 2019 USD ($) $ / shares | Dec. 31, 2018 USD ($) $ / shares
SARs |  |
Changes in the fair value of warrant liability and SARs liability |  |
December 31, 2018 | $ 3,814 |
Change in fair value | 1,035 |
Payments | (3,815) |
March 31, 2019 | 1,034 |
Commitments |  |
Changes in the fair value of warrant liability and SARs liability |  |
December 31, 2018 | 257,040 |
Additions | 13,760 |
Payments | 0 |
March 31, 2019 | 270,800 |
SARs |  |
Changes in the fair value of warrant liability and SARs liability |  |
December 31, 2018 | 3,814 |
March 31, 2019 | $ 1,034 |
Measurement Input, Option Volatility | SARs |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.57 |
Measurement Input, Risk Free Interest Rate | SARs |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.02 |
Measurement Input, Expected Term | SARs |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.76 |
Minimum | Warrants |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | $ / shares | 128.00 | 128.00
Minimum | SARs |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | $ / shares | 6.76 | 6.76
Minimum | Measurement Input, Option Volatility | Warrants |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.58 | 0.59
Minimum | Measurement Input, Option Volatility | SARs |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input |  | 0.47
Minimum | Measurement Input, Risk Free Interest Rate | SARs |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input |  | 0.02
Minimum | Measurement Input, Expected Term | Warrants |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.35 | 0.59
Minimum | Measurement Input, Expected Term | SARs |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input |  | 0.01
Maximum | Warrants |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | $ / shares | 2,520.00 | 2,520.00
Maximum | SARs |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | $ / shares | 30.86 | 30.86
Maximum | Measurement Input, Option Volatility | Warrants |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.62 | 0.60
Maximum | Measurement Input, Option Volatility | SARs |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input |  | 0.60
Maximum | Measurement Input, Risk Free Interest Rate | SARs |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input |  | 0.03
Maximum | Measurement Input, Expected Term | Warrants |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.48 | 0.72
Maximum | Measurement Input, Expected Term | SARs |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input |  | 1.01
Common stock | Measurement Input, Share Price | SARs |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | $ / shares | 37.64 | 34.32
Milestones and Royalties | Minimum | Probability of Success [Member] | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.25 | 0.25
Milestones and Royalties | Maximum | Probability of Success [Member] | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.89 | 0.89
Development and Regulatory Milestone | Minimum | Probability of Success [Member] | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.25 | 0.25
Development and Regulatory Milestone | Maximum | Probability of Success [Member] | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.94 | 0.94
Agilis | Milestones and Royalties |  |
Changes in the fair value of warrant liability and SARs liability |  |
December 31, 2018 | $ 53,200 |
March 31, 2019 | $ 60,100 |
Agilis | Milestones and Royalties | Measurement Input, Discount Rate | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.135 | 0.140
Agilis | Milestones and Royalties | Minimum | Sales Milestones | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Milestone | $ 0 | $ 0
Agilis | Milestones and Royalties | Minimum | Percentage of Sales for Royalties | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.02 | 0.02
Agilis | Milestones and Royalties | Maximum | Sales Milestones | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Milestone | $ 150,000 | $ 0
Agilis | Milestones and Royalties | Maximum | Percentage of Sales for Royalties | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.06 | 0.06
Agilis | Development and Regulatory Milestone |  |
Changes in the fair value of warrant liability and SARs liability |  |
December 31, 2018 | $ 257,040 |
March 31, 2019 | 270,800 |
Agilis | Development and Regulatory Milestone | Minimum | Development and Regulatory Milestone | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Milestone | $ 0 | $ 0
Agilis | Development and Regulatory Milestone | Minimum | Measurement Input, Discount Rate | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.04 | 0.06
Agilis | Development and Regulatory Milestone | Maximum | Development and Regulatory Milestone | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Milestone | $ 555,000 | $ 0
Agilis | Development and Regulatory Milestone | Maximum | Measurement Input, Discount Rate | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.06 | 0.08
Significant unobservable inputs (level 3) | Agilis |  |
Changes in the fair value of warrant liability and SARs liability |  |
December 31, 2018 | $ 53,200 |
March 31, 2019 | 60,100 |
Significant unobservable inputs (level 3) | Agilis | Milestones and Royalties |  |
Changes in the fair value of warrant liability and SARs liability |  |
December 31, 2018 | 53,200 |
Change in fair value | 6,900 |
March 31, 2019 | $ 60,100 |

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