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Stock award plan (Tables)

3 Months Ended

Mar. 31, 2019

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Summary of stock option activity

A summary of stock option activity is as follows:

		Number of options			Weighted- average exercise price				Weighted- average remaining contractual term		Aggregate intrinsic value
											(in thousands)
Outstanding at December 31, 2018		8,534,358			$	28.58
Granted		2,490,970			$	33.01
Exercised		(80,826	)		$	15.85
Forfeited/Cancelled		(133,119	)		$	29.10
Outstanding at March 31, 2019		10,811,383			$	29.67			7.72 years		$	117,201
Vested or Expected to vest at March 31, 2019		5,364,300			$	28.40			9.15 years		$	53,343
Exercisable at March 31, 2019		4,987,460			$	31.00			6.04 years		$	60,063

Schedule of assumptions used to estimate fair values of grants made on the date of grant

The fair value of grants made in the three months ended March 31, 2019 was contemporaneously estimated on the date of grant using the following assumptions:

		Three months ended March 31, 2019
Risk-free interest rate		2.53 - 2.63%
Expected volatility		62.62 - 63.01%
Expected term		6.11 years

Summary of information on the Company's restricted stock

The following table summarizes information on the Company’s restricted stock awards and units:

		Restricted Stock Awards and Units
		Number of Shares			Weighted Average Grant Date Fair Value
January 1, 2019		571,479			$	17.61
Granted		304,549			$	32.94
Vested		(161,077	)		$	17.60
Forfeited		(19,612	)		$	20.42
Unvested at March 31, 2019		695,339			$	24.27

Schedule of share-based compensation expense recorded in the statement of operations

The Company recorded share-based compensation expense in the statement of operations related to incentive stock options, nonstatutory stock options, restricted stock awards, restricted stock units and the ESPP as follows:

		Three Months Ended March 31,
		2019				2018
Research and development		$	4,686			$	3,747
Selling, general and administrative		4,577				4,001
Total		$	9,263			$	7,748

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Tabular disclosure of the changes in outstanding nonvested restricted stock shares.

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
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-Section 50
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Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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