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Consolidated Statements of Operations (unaudited) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Performance obligations satisfied in current period   $ 55,981
Revenues:    
Revenue $ 53,583 56,062
Operating expenses:    
Cost of product sales, excluding amortization of acquired intangible asset 2,376 3,045
Amortization of acquired intangible asset 6,077 5,428
Research and development 52,566 31,363
Selling, general and administrative 40,544 32,969
Change in the fair value of deferred and contingent consideration 21,160 0
Total operating expenses 122,723 72,805
Loss from operations (69,140) (16,743)
Interest expense, net (2,288) (3,303)
Other (expense) income, net (109) 1,004
Loss before income tax expense (71,537) (19,042)
Income tax expense 576 (221)
Net loss attributable to common stockholders $ (72,113) $ (19,263)
Weighted-average shares outstanding:    
Basic and diluted (in shares) 55,855,111 41,626,617
Net loss per share-basic and diluted (in dollars per share)    
Net loss per share—basic and diluted (in dollars per share) $ (1.29) $ (0.46)
Net product revenue    
Revenues:    
Revenue $ 53,054 $ 55,981
Collaboration and grant revenue    
Revenues:    
Revenue $ 529