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Fair value of financial instruments and marketable securities - Narrative (Details) - USD ($)	3 Months Ended	12 Months Ended
	Mar. 31, 2019	Dec. 31, 2017	Jan. 31, 2019	Dec. 31, 2018	Aug. 23, 2018	Aug. 31, 2015
Financial assets and liabilities measured at fair value on recurring basis
Transfers of assets between Level 1 and Level 2 of the fair value measurement hierarchy	$ 0			$ 0
Realized gain (loss)	0	$ 0
Fair value of shares (in dollars per share)			$ 30.20
Estimated fair value of deferred consideration payable	18,900,000			18,300,000
Deferred consideration payable	19,300,000			19,400,000
3.00% Convertible senior notes due 2022 | Convertible debt
Financial assets and liabilities measured at fair value on recurring basis
Principal	150,000,000			150,000,000		$ 150,000,000.0
Interest rate ( as a percent )						3.00%
Fair value of convertible notes	$ 154,300,000			146,600,000
Agilis
Financial assets and liabilities measured at fair value on recurring basis
Development milestone payments which the entity is obligated to pay					$ 40,000,000
Agilis | Minimum
Financial assets and liabilities measured at fair value on recurring basis
Milestone, potential achievements, product sales	2.00%
Agilis | Maximum
Financial assets and liabilities measured at fair value on recurring basis
Milestone, potential achievements, product sales	6.00%
Development milestone payments which the entity is obligated to pay	$ 60,000,000
Milestone, potential achievements, priority review voucher amount	535,000,000
Milestone, potential achievements, net sales amount	150,000,000
Non-collaborative Arrangement Transactions | Agilis
Financial assets and liabilities measured at fair value on recurring basis
Development milestone payments which the entity is obligated to pay	40,000,000
Recurring basis | Total
Financial assets and liabilities measured at fair value on recurring basis
Estimated fair value of deferred consideration payable	$ 38,200,000			$ 37,700,000

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