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Fair value of financial instruments and marketable securities - Warrants and SARs (Details) $ in Thousands	3 Months Ended
	Mar. 31, 2019 USD ($) $ / shares	Dec. 31, 2018 USD ($) $ / shares
SARs
Changes in the fair value of warrant liability and SARs liability
December 31, 2018	$ 3,814
Change in fair value	1,035
Payments	(3,815)
March 31, 2019	1,034
Commitments
Changes in the fair value of warrant liability and SARs liability
December 31, 2018	257,040
Additions	13,760
Payments	0
March 31, 2019	270,800
SARs
Changes in the fair value of warrant liability and SARs liability
December 31, 2018	3,814
March 31, 2019	$ 1,034
Measurement Input, Option Volatility | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input	0.57
Measurement Input, Risk Free Interest Rate | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input	0.02
Measurement Input, Expected Term | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input	0.76
Minimum | Warrants
Fair value of warrant liability
Alternative Investment, Measurement Input | $ / shares	128.00	128.00
Minimum | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input | $ / shares	6.76	6.76
Minimum | Measurement Input, Option Volatility | Warrants
Fair value of warrant liability
Alternative Investment, Measurement Input	0.58	0.59
Minimum | Measurement Input, Option Volatility | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input		0.47
Minimum | Measurement Input, Risk Free Interest Rate | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input		0.02
Minimum | Measurement Input, Expected Term | Warrants
Fair value of warrant liability
Alternative Investment, Measurement Input	0.35	0.59
Minimum | Measurement Input, Expected Term | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input		0.01
Maximum | Warrants
Fair value of warrant liability
Alternative Investment, Measurement Input | $ / shares	2,520.00	2,520.00
Maximum | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input | $ / shares	30.86	30.86
Maximum | Measurement Input, Option Volatility | Warrants
Fair value of warrant liability
Alternative Investment, Measurement Input	0.62	0.60
Maximum | Measurement Input, Option Volatility | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input		0.60
Maximum | Measurement Input, Risk Free Interest Rate | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input		0.03
Maximum | Measurement Input, Expected Term | Warrants
Fair value of warrant liability
Alternative Investment, Measurement Input	0.48	0.72
Maximum | Measurement Input, Expected Term | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input		1.01
Common stock | Measurement Input, Share Price | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input | $ / shares	37.64	34.32
Milestones and Royalties | Minimum | Probability of Success [Member] | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.25	0.25
Milestones and Royalties | Maximum | Probability of Success [Member] | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.89	0.89
Development and Regulatory Milestone | Minimum | Probability of Success [Member] | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.25	0.25
Development and Regulatory Milestone | Maximum | Probability of Success [Member] | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.94	0.94
Agilis | Milestones and Royalties
Changes in the fair value of warrant liability and SARs liability
December 31, 2018	$ 53,200
March 31, 2019	$ 60,100
Agilis | Milestones and Royalties | Measurement Input, Discount Rate | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.135	0.140
Agilis | Milestones and Royalties | Minimum | Sales Milestones | Commitments
Fair value of warrant liability
Alternative Investment, Milestone	$ 0	$ 0
Agilis | Milestones and Royalties | Minimum | Percentage of Sales for Royalties | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.02	0.02
Agilis | Milestones and Royalties | Maximum | Sales Milestones | Commitments
Fair value of warrant liability
Alternative Investment, Milestone	$ 150,000	$ 0
Agilis | Milestones and Royalties | Maximum | Percentage of Sales for Royalties | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.06	0.06
Agilis | Development and Regulatory Milestone
Changes in the fair value of warrant liability and SARs liability
December 31, 2018	$ 257,040
March 31, 2019	270,800
Agilis | Development and Regulatory Milestone | Minimum | Development and Regulatory Milestone | Commitments
Fair value of warrant liability
Alternative Investment, Milestone	$ 0	$ 0
Agilis | Development and Regulatory Milestone | Minimum | Measurement Input, Discount Rate | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.04	0.06
Agilis | Development and Regulatory Milestone | Maximum | Development and Regulatory Milestone | Commitments
Fair value of warrant liability
Alternative Investment, Milestone	$ 555,000	$ 0
Agilis | Development and Regulatory Milestone | Maximum | Measurement Input, Discount Rate | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.06	0.08
Significant unobservable inputs (level 3) | Agilis
Changes in the fair value of warrant liability and SARs liability
December 31, 2018	$ 53,200
March 31, 2019	60,100
Significant unobservable inputs (level 3) | Agilis | Milestones and Royalties
Changes in the fair value of warrant liability and SARs liability
December 31, 2018	53,200
Change in fair value	6,900
March 31, 2019	$ 60,100

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