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Revenue recognition - Narrative (Details)	1 Months Ended					3 Months Ended		12 Months Ended
	Oct. 31, 2017 USD ($)	Nov. 30, 2014 USD ($)	Jan. 31, 2014 USD ($)	Aug. 31, 2013 USD ($)	Nov. 30, 2011 USD ($) compound	Mar. 31, 2019 USD ($) segment deliverable	Mar. 31, 2018 USD ($)	Dec. 31, 2017 USD ($) deliverable	Dec. 31, 2018 USD ($)
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Contract with Customer, Liability						$ 14,350,000	$ 9,300,000	$ 11,891,000	$ 12,938,000
Number of operating segments | segment						1
Net product revenue						$ 53,054,000	55,981,000
Upfront cash payment						1,412,000	1,346,000
Revenue						53,583,000	56,062,000
Performance obligations satisfied in current period							55,981,000
Licensing And Collaboration Agreement
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Upfront cash payment					$ 30,000,000
Performance obligations satisfied in current period	$ 20,000,000	$ 10,000,000	$ 7,500,000	$ 10,000,000
Licensing And Collaboration Agreement | Research And Development Event Milestones
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Revenue recognition, milestone, potential achievements					135,000,000	87,500,000
Licensing And Collaboration Agreement | Sales Milestones
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Revenue recognition, milestone, potential achievements					$ 325,000,000	325,000,000
Discovery Agreements
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Revenues						0	0
Early Stage Collaborations
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Revenues						0	0
Early Stage Collaborations | Research And Development Event Milestones
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Revenue recognition, milestone, potential achievements						143,000,000
Early Stage Collaborations | Sales Milestones
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Revenue recognition, milestone, potential achievements						252,000,000
United States
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Net product revenue						17,800,000	19,200,000
Non-US
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Net product revenue						$ 35,300,000	36,800,000
Collaborative Arrangement | Roche And Sma Foundation
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Number of compounds in preclinical development | compound					3
Number of significant deliverables | deliverable								2
Collaboration And Discovery Agreements
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Number of significant deliverables | deliverable						2
Minimum | Collaboration And Discovery Agreements
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Collaborative arrangements research period for applying discovery technology						3 years
Maximum | Collaboration And Discovery Agreements
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Collaborative arrangements research period for applying discovery technology						4 years
Roche | Licensing And Collaboration Agreement
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Revenues						$ 100,000	$ 100,000

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Revenue Recognition, Milestone, Potential Achievements

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Amount of obligation to transfer good or service to customer for which consideration has been received or is receivable.

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Number of operating segments. An operating segment is a component of an enterprise: (a) that engages in business activities from which it may earn revenues and incur expenses (including revenues and expenses relating to transactions with other components of the same enterprise), (b) whose operating results are regularly reviewed by the enterprise's chief operating decision maker to make decisions about resources to be allocated to the segment and assess its performance, and (c) for which discrete financial information is available. An operating segment may engage in business activities for which it has yet to earn revenues, for example, start-up operations may be operating segments before earning revenues.

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