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Revenue recognition - Income Statement Impacts (Details) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Revenues:    
Revenue $ 53,583 $ 56,062
Operating expenses:    
Cost of product sales, excluding amortization of acquired intangible asset 2,376 3,045
Amortization of acquired intangible asset 6,077 5,428
Research and development 52,566 31,363
Selling, general and administrative 40,544 32,969
Total operating expenses 122,723 72,805
Loss from operations (69,140) (16,743)
Interest expense, net (2,288) (3,303)
Other (expense) income, net (109) 1,004
Loss before income tax expense (71,537) (19,042)
Income tax expense 576 (221)
Net loss attributable to common stockholders (72,113) (19,263)
Net product revenue    
Revenues:    
Revenue 53,054 $ 55,981
Collaboration and grant revenue    
Revenues:    
Revenue $ 529