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Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Cash flows from operating activities
Net loss	$ (72,113)	$ (19,263)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	7,059	6,022
Change in valuation of deferred and contingent consideration	21,160	0
Non-cash interest expense	1,982	1,780
Amortization of (discounts) premiums on investments, net	(257)	(96)
Amortization of debt issuance costs	139	126
Share-based compensation expense	9,263	7,748
Unrealized foreign currency transaction losses (gains), net	865	(1,300)
Changes in operating assets and liabilities:
Inventory	(334)	(1,446)
Prepaid expenses and other current assets	(191)	958
Trade receivables, net	20,786	(4,223)
Deposits and other assets	(10,754)	(308)
Accounts payable and accrued expenses	(28,653)	(6,810)
Other liabilities	8,065	(475)
Deferred revenue	574	1,409
Net cash used in operating activities	(42,409)	(15,878)
Cash flows from investing activities
Purchases of fixed assets	(2,865)	(479)
Purchases of marketable securities	(165,723)	(22,683)
Sale and redemption of marketable securities	18,090	21,514
Net cash used in investing activities	(150,498)	(1,648)
Cash flows from financing activities
Proceeds from exercise of options	1,281	1,136
Net proceeds from public offerings	224,441	0
Net cash provided by financing activities	225,722	1,136
Effect of exchange rate changes on cash	(1,169)	2,273
Net increase in cash and cash equivalents	31,646	(14,117)
Cash and cash equivalents, beginning of period	169,498	111,792
Cash and cash equivalents, end of period	201,144	97,675
Supplemental disclosure of cash information
Cash paid for interest	3,111	3,023
Cash paid for income taxes	537	326
Supplemental disclosure of non-cash investing and financing activity
Unrealized gain (loss) on marketable securities	59	(123)
Right-of-use assets obtained in exchange for lease obligations	$ 11,314	$ 0

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