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Accounts payable and accrued expenses - Narrative (Details) - USD ($) $ in Thousands | Jun. 30, 2019 | Dec. 31, 2018
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Payables and Accruals [Abstract] |  |
Employee compensation, benefits, and related accruals | $ 19,039 | $ 27,629
Consulting and contracted research | 12,373 | 11,267
Professional fees | 4,116 | 5,574
Sales allowance and other costs | 36,794 | 29,417
Sales rebates and royalties | 29,449 | 31,874
Accounts payable | 10,219 | 6,001
Other | 10,385 | 16,437
Accounts payable and accrued expenses | $ 122,375 | $ 128,199

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