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v3.19.2

Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2019 | Jun. 30, 2018
Cash flows from operating activities |  |
Net loss | $ (113,902) | $ (28,782)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 14,760 | 12,243
Change in valuation of deferred and contingent consideration | 26,460 | 0
Unrealized gain on MRI investment | (129) | 0
Non-cash interest expense | 4,055 | 3,644
Loss on disposal of asset | (50) | 0
Amortization of discounts on investments, net | (907) | (230)
Amortization of debt issuance costs | 280 | 256
Share-based compensation expense | 20,184 | 15,831
Unrealized foreign currency transaction gains, net | 62 | (764)
Changes in operating assets and liabilities: |  |
Inventory | (852) | (3,393)
Prepaid expenses and other current assets | (7,250) | 254
Trade receivables, net | (9,702) | (20,429)
Deposits and other assets | (9,656) | (419)
Accounts payable and accrued expenses | (7,546) | 2,225
Other liabilities | 8,651 | 485
Deferred revenue | 2,511 | 3,204
Net cash used in operating activities | (72,931) | (15,875)
Cash flows from investing activities |  |
Purchases of fixed assets | (4,851) | (1,187)
Purchases of equity investment in MRI | (4,000) | 0
Purchases of marketable securities | (226,261) | (28,656)
Sale and redemption of marketable securities | 58,424 | 35,939
Acquisition of product rights and licenses | 11,981 | 0
Net cash used in (provided by) investing activities | (188,669) | 6,096
Cash flows from financing activities |  |
Proceeds from exercise of options | 4,129 | 3,592
Net proceeds from public offerings | 224,545 | 117,874
Repayments of Debt | 1,667 | 0
Proceeds from shares issued under employee stock purchase plan | 1,564 | 1,299
Net cash provided by financing activities | 228,571 | 122,765
Effect of exchange rate changes on cash | (375) | (990)
Net (decrease) increase in cash and cash equivalents | (33,404) | 111,996
Cash and cash equivalents, beginning of period | 169,498 | 111,792
Cash and cash equivalents, end of period | 136,094 | 223,788
Supplemental disclosure of cash information |  |
Cash paid for interest | 3,111 | 3,838
Cash paid for income taxes | 1,013 | 758
Supplemental disclosure of non-cash investing and financing activity |  |
Unrealized gain (loss) on marketable securities | 898 | (83)
Right-of-use assets obtained in exchange for lease obligations | 11,643 | 0
Noncash or Part Noncash Acquisition, Intangible Assets Acquired | $ 8,269 | $ 3,903

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- Definition The cash outflow associated with the purchase of or advances to an equity method investments, which are investments in joint ventures and entities in which the entity has an equity ownership interest normally of 20 to 50 percent and exercises significant influence. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3213-108585 + Details
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- Definition Amount of cash outflow for purchase of marketable security. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=118954083&loc=d3e26853-111562 + Details
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- Definition The cash outflow for purchases of and capital improvements on property, plant and equipment (capital expenditures), software, and other intangible assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3213-108585 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3213-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with the aggregate amount received by the entity through sale or maturity of marketable securities (held-to-maturity or available-for-sale) during the period. + References No definition available. + Details
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- Definition Amount of cash inflow from exercise of option under share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2A -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=116856206&loc=SL79508275-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with the amount received from the stock plan during the period. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3255-108585 + Details
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- Definition The cash outflow during the period from the repayment of aggregate short-term and long-term debt. Excludes payment of capital lease obligations. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3291-108585 + Details
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- Definition Amount of increase in right-of-use asset obtained in exchange for operating lease liability. + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Publisher FASB -Name Accounting Standards Codification -Topic 842 -SubTopic 20 -Section 55 -Paragraph 53 -URI http://asc.fasb.org/extlink&oid=77888399&loc=SL77918982-209971 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 842 -SubTopic 20 -Section 50 -Paragraph 4 -Subparagraph (g)(2) -URI http://asc.fasb.org/extlink&oid=77888426&loc=SL77918686-209980 + Details
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- Definition Amount of noncash expense for share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3602-108585 + Details
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- Definition The net change in the difference between the fair value and the carrying value, or in the comparative fair values, of investments, not including unrealized gains or losses on securities separately or otherwise categorized as trading, available-for-sale, or held-to-maturity, held at each balance sheet date and included in earnings for the period. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3602-108585 + Details
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