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Consolidated Statements of Stockholders' Equity - USD ($) | Total | Common stock | Additional paid-in capital | AOCI Attributable to Parent | Accumulated deficit
--- | --- | --- | --- | --- | ---
Balance (in shares) at Dec. 31, 2017 |  | 41,612,395 |  |  |
Balance at the beginning of the period at Dec. 31, 2017 | $ 156,437,000 | $ 42,000 | $ 966,534,000 | $ 3,969,000 | $ (814,108,000)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock related to equity offering (in shares) |  | 4,600,000 |  |  |
Issuance of common stock related to equity offering | 117,874,000 | $ 5,000 | 117,869,000 |  |
Exercised (in shares) |  | 260,879 |  |  |
Exercise of options | 3,592,000 | $ 0 | 3,592,000 |  |
Issuance of restricted stock (in shares) |  | 119,691 |  |  |
Restricted stock vesting and issuance | 0 |  |  |  |
Issuance of common stock in connection with an employee stock purchase plan (in shares) |  | 87,517 |  |  |
Issuance of common stock in connection with an employee stock purchase plan | 1,299,000 | $ 0 | 1,299,000 |  |
Share-based compensation expense | 15,831,000 |  | 15,831,000 |  |
Net loss | (28,782,000) |  |  |  | (28,782,000)
Comprehensive income | (2,114,000) |  |  | (2,114,000) |
Balance (in shares) at Jun. 30, 2018 |  | 46,680,482 |  |  |
Balance at the end of the period at Jun. 30, 2018 | 267,402,000 | $ 47,000 | 1,105,124,000 | 1,855,000 | (839,624,000)
Balance (in shares) at Mar. 31, 2018 |  | 41,809,398 |  |  |
Balance at the beginning of the period at Mar. 31, 2018 | 150,309,000 | $ 42,000 | 975,418,000 | 4,953,000 | (830,104,000)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock related to equity offering (in shares) |  | 4,600,000 |  |  |
Issuance of common stock related to equity offering | 117,874,000 | $ 5,000 | 117,869,000 |  |
Exercised (in shares) |  | 183,567 |  |  |
Exercise of options | 2,455,000 |  | 2,455,000 |  |
Restricted stock vesting and issuance | 0 |  |  |  |
Issuance of common stock in connection with an employee stock purchase plan (in shares) |  | 87,517 |  |  |
Issuance of common stock in connection with an employee stock purchase plan | 1,298,000 | $ 0 | 1,298,000 |  |
Share-based compensation expense | 8,084,000 |  | 8,084,000 |  |
Net loss | (9,520,000) |  |  |  | (9,520,000)
Comprehensive income | (3,098,000) |  |  | (3,098,000) |
Balance (in shares) at Jun. 30, 2018 |  | 46,680,482 |  |  |
Balance at the end of the period at Jun. 30, 2018 | 267,402,000 | $ 47,000 | 1,105,124,000 | 1,855,000 | (839,624,000)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Adjustment to accumulated deficit | 3,265,000 |  | (1,000) |  | 3,266,000
Balance (in shares) at Dec. 31, 2018 |  | 50,606,147 |  |  |
Balance at the beginning of the period at Dec. 31, 2018 | 350,727,000 | $ 51,000 | 1,288,137,000 | 1,462,000 | (938,923,000)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock related to equity offering (in shares) |  | 7,563,725 |  |  |
Issuance of common stock related to equity offering | 224,545,000 | $ 7,000 | 224,538,000 |  |
Exercised (in shares) |  | 311,002 |  |  |
Exercise of options | 4,129,000 | $ 0 | 4,129,000 |  |
Restricted stock vesting and issuance (in shares) |  | 171,592 |  |  |
Restricted stock vesting and issuance | 0 | $ 0 |  |  |
Issuance of common stock in connection with an employee stock purchase plan (in shares) |  | 54,719 |  |  |
Issuance of common stock in connection with an employee stock purchase plan | 1,564,000 | $ 0 | 1,564,000 |  |
Share-based compensation expense | 20,184,000 |  | 20,184,000 |  |
Adjustments to Additional Paid In Capital, Receivable from Investor | 978,000 |  | 978,000 |  |
Net loss | (113,902,000) |  |  |  | (113,902,000)
Comprehensive income | 460,000 |  |  | 460,000 |
Balance (in shares) at Jun. 30, 2019 |  | 58,707,185 |  |  |
Balance at the end of the period at Jun. 30, 2019 | 488,685,000 | $ 58,000 | 1,539,530,000 | 1,922,000 | (1,052,825,000)
Balance (in shares) at Mar. 31, 2019 |  | 58,418,790 |  |  |
Balance at the beginning of the period at Mar. 31, 2019 | 512,942,000 | $ 58,000 | 1,523,115,000 | 805,000 | (1,011,036,000)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock related to equity offering (in shares) |  | 0 |  |  |
Issuance of common stock related to equity offering | 106,000 | $ 0 | 106,000 |  |
Exercised (in shares) |  | 230,176 |  |  |
Exercise of options | 2,847,000 | $ 0 | 2,847,000 |  |
Restricted stock vesting and issuance (in shares) |  | 3,500 |  |  |
Issuance of common stock in connection with an employee stock purchase plan (in shares) |  | 54,719 |  |  |
Issuance of common stock in connection with an employee stock purchase plan | 1,564,000 | $ 0 | 1,564,000 |  |
Share-based compensation expense | 10,920,000 |  | 10,920,000 |  |
Adjustments to Additional Paid In Capital, Receivable from Investor | 978,000 |  | 978,000 |  |
Net loss | (41,789,000) |  |  |  | (41,789,000)
Comprehensive income | 1,117,000 |  |  | 1,117,000 |
Balance (in shares) at Jun. 30, 2019 |  | 58,707,185 |  |  |
Balance at the end of the period at Jun. 30, 2019 | $ 488,685,000 | $ 58,000 | $ 1,539,530,000 | $ 1,922,000 | $ (1,052,825,000)

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