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Fair value of financial instruments and marketable securities - Narrative (Details) - USD ($) | 3 Months Ended | 6 Months Ended |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | ---
Jun. 30, 2019 | Jun. 30, 2019 | Jun. 30, 2018 | May 31, 2019 | Jan. 31, 2019 | Dec. 31, 2018 | Aug. 23, 2018 | Aug. 31, 2015
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Realized gain (loss) |  | $ 0 |  |  |  |  |  |
Fair value of shares (in dollars per share) |  |  |  |  | $ 30.20 |  |  |
Estimated fair value of deferred consideration payable | $ 18,800,000 | 18,800,000 |  |  |  | $ 18,300,000 |  |
Deferred consideration payable | 19,400,000 | 19,400,000 |  |  |  | 19,400,000 |  |
Unrealized Gain (Loss) on Investments |  | 129,000 | $ 0 |  |  |  |  |
Investment In MRI | 4,100,000 | 4,100,000 |  |  |  |  |  |
3.00% Convertible senior notes due 2022 | Convertible debt |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Principal | 150,000,000 | 150,000,000 |  |  |  | 150,000,000 |  | $ 150,000,000.0
Interest rate ( as a percent ) |  |  |  |  |  |  |  | 3.00%
Fair value of convertible notes | $ 166,200,000 | $ 166,200,000 |  |  |  | 146,600,000 |  |
Agilis |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Development milestone payments which the entity is obligated to pay |  |  |  |  |  |  | $ 40,000,000.0 |
Agilis | Minimum |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Milestone, potential achievements, product sales | 2.00% | 2.00% |  |  |  |  |  |
Agilis | Maximum |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Milestone, potential achievements, product sales | 6.00% | 6.00% |  |  |  |  |  |
Development milestone payments which the entity is obligated to pay | $ 60,000,000.0 | $ 60,000,000.0 |  |  |  |  |  |
Milestone, potential achievements, priority review voucher amount |  | 535,000,000.0 |  |  |  |  |  |
Milestone, potential achievements, net sales amount | 150,000,000.0 | 150,000,000.0 |  |  |  |  |  |
Non-collaborative Arrangement Transactions | Agilis |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Development milestone payments which the entity is obligated to pay | 40,000,000.0 | 40,000,000.0 |  |  |  |  |  |
Recurring basis | Total |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Estimated fair value of deferred consideration payable | 38,200,000 | 38,200,000 |  |  |  | $ 37,700,000 |  |
Common stock |  |  |  |  |  |  |  |
Financial assets and liabilities measured at fair value on recurring basis |  |  |  |  |  |  |  |
Investment Owned, Balance, Shares |  |  |  | $ 4,000,000.0 |  |  |  |
Fair value of shares (in dollars per share) |  |  |  | $ 3.10 |  |  |  |
Unrealized Gain (Loss) on Investments | $ 100,000 | $ 100,000 |  |  |  |  |  |

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