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Stock award plan - (Tables)

6 Months Ended

Jun. 30, 2019

Share-based Payment Arrangement [Abstract]

Summary of stock option activity

A summary of stock option activity is as follows:

		Number of options			Weighted- average exercise price				Weighted- average remaining contractual term		Aggregate intrinsic value (in thousands)
Outstanding at December 31, 2018		8,534,358			$	28.58
Granted		2,845,620			$	33.54
Exercised		(311,002	)		$	16.50
Forfeited/Cancelled		(215,675	)		$	36.10
Outstanding at June 30, 2019		10,853,301			$	30.07			7.59 years		$	178,906
Vested or Expected to vest at June 30, 2019		5,334,168			$	29.22			9.01 years		$	84,446
Exercisable at June 30, 2019		5,138,717			$	30.90			5.98 years		$	88,423

Schedule of assumptions used to estimate fair values of grants made on the date of grant

The fair value of grants made in the six months ended June 30, 2019 was contemporaneously estimated on the date of grant using the following assumptions:

		Six months ended June 30, 2019
Risk-free interest rate		1.98 - 2.63%
Expected volatility		61.90 - 63.09%
Expected term		6.11 years

Summary of information on the Company's restricted stock

The following table summarizes information on the Company’s restricted stock awards and units:

		Restricted Stock Awards and Units
		Number of Shares			Weighted Average Grant Date Fair Value
January 1, 2019		571,479			$	17.61
Granted		304,549			$	32.94
Vested		(179,577	)		$	17.54
Forfeited		(31,449	)		$	21.47
Unvested at June 30, 2019		665,002			$	24.45

Schedule of share-based compensation expense recorded in the statement of operations

The Company recorded share-based compensation expense in the statement of operations related to incentive stock options, nonstatutory stock options, restricted stock awards, restricted stock units and the ESPP as follows:

		Three Months Ended June 30,								Six Months Ended June 30,
		2019				2018				2019				2018
Research and development		$	5,516			$	3,932			$	10,203			$	7,678
Selling, general and administrative		5,404				4,152				9,981				8,153
Total		$	10,920			$	8,084			$	20,184			$	15,831

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Tabular disclosure of the changes in outstanding nonvested restricted stock shares.

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
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-Section 50
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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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