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Fair value of financial instruments and marketable securities - Narrative (Details) - USD ($)	3 Months Ended	6 Months Ended
	Jun. 30, 2019	Jun. 30, 2019	Jun. 30, 2018	May 31, 2019	Jan. 31, 2019	Dec. 31, 2018	Aug. 23, 2018	Aug. 31, 2015
Financial assets and liabilities measured at fair value on recurring basis
Realized gain (loss)		$ 0
Fair value of shares (in dollars per share)					$ 30.20
Estimated fair value of deferred consideration payable	$ 18,800,000	18,800,000				$ 18,300,000
Deferred consideration payable	19,400,000	19,400,000				19,400,000
Unrealized Gain (Loss) on Investments		129,000	$ 0
Investment In MRI	4,100,000	4,100,000
3.00% Convertible senior notes due 2022 | Convertible debt
Financial assets and liabilities measured at fair value on recurring basis
Principal	150,000,000	150,000,000				150,000,000		$ 150,000,000.0
Interest rate ( as a percent )								3.00%
Fair value of convertible notes	$ 166,200,000	$ 166,200,000				146,600,000
Agilis
Financial assets and liabilities measured at fair value on recurring basis
Development milestone payments which the entity is obligated to pay							$ 40,000,000.0
Agilis | Minimum
Financial assets and liabilities measured at fair value on recurring basis
Milestone, potential achievements, product sales	2.00%	2.00%
Agilis | Maximum
Financial assets and liabilities measured at fair value on recurring basis
Milestone, potential achievements, product sales	6.00%	6.00%
Development milestone payments which the entity is obligated to pay	$ 60,000,000.0	$ 60,000,000.0
Milestone, potential achievements, priority review voucher amount		535,000,000.0
Milestone, potential achievements, net sales amount	150,000,000.0	150,000,000.0
Non-collaborative Arrangement Transactions | Agilis
Financial assets and liabilities measured at fair value on recurring basis
Development milestone payments which the entity is obligated to pay	40,000,000.0	40,000,000.0
Recurring basis | Total
Financial assets and liabilities measured at fair value on recurring basis
Estimated fair value of deferred consideration payable	38,200,000	38,200,000				$ 37,700,000
Common stock
Financial assets and liabilities measured at fair value on recurring basis
Investment Owned, Balance, Shares				$ 4,000,000.0
Fair value of shares (in dollars per share)				$ 3.10
Unrealized Gain (Loss) on Investments	$ 100,000	$ 100,000

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