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Consolidated Statements of Operations (unaudited) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Performance obligations satisfied in current period	$ 85,476	$ 68,170	$ 138,530	$ 124,151
Revenues:
Revenue	85,522	68,743	139,105	124,805
Operating expenses:
Cost of product sales, excluding amortization of acquired intangible assets	3,211	2,572	5,587	5,616
Amortization of acquired intangible assets	6,575	5,593	12,652	11,022
Research and development	59,979	32,607	112,544	63,970
Selling, general and administrative	49,215	33,545	89,760	66,514
Change in the fair value of deferred and contingent consideration	5,300	0	26,460	0
Total operating expenses	124,280	74,317	247,003	147,122
Loss from operations	(38,758)	(5,574)	(107,898)	(22,317)
Interest expense, net	(2,074)	(2,884)	(4,362)	(6,187)
Other (expense) income, net	(183)	(673)	(292)	332
Loss before income tax expense	(41,015)	(9,131)	(112,552)	(28,172)
Income tax expense	(774)	(389)	(1,350)	(610)
Net loss attributable to common stockholders	$ (41,789)	$ (9,520)	$ (113,902)	$ (28,782)
Weighted-average shares outstanding:
Basic and diluted (in shares)	55,912,748	46,137,833	57,113,141	46,257,397
Net loss per share-basic and diluted (in dollars per share)
Net loss per share—basic and diluted (in dollars per share)	$ (0.75)	$ (0.21)	$ (1.99)	$ (0.62)
Net product revenue
Revenues:
Revenue		$ 68,170	$ 138,530	$ 124,151
Collaboration and grant revenue
Revenues:
Revenue	$ 46	$ 573	$ 575	$ 654

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