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Fair value of financial instruments and marketable securities - Warrants and SARs (Details) $ in Thousands	6 Months Ended	12 Months Ended
	Jun. 30, 2019 USD ($) $ / shares	Dec. 31, 2018 USD ($) $ / shares
Changes in the fair value of warrant liability and SARs liability
Additions	$ 0
SARs
Changes in the fair value of warrant liability and SARs liability
December 31, 2018	3,814
Change in fair value	1,961
Payments	(3,815)
June 30, 2019	1,960	$ 3,814
Commitments
Changes in the fair value of warrant liability and SARs liability
December 31, 2018	257,040
Additions	0
Change in fair value	20,360
Payments
June 30, 2019	277,400	257,040
SARs
Changes in the fair value of warrant liability and SARs liability
December 31, 2018	3,814
June 30, 2019	$ 1,960	$ 3,814
Measurement Input, Option Volatility | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input	0.4970
Measurement Input, Risk Free Interest Rate | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input	0.0209
Measurement Input, Expected Term | SARs
Fair value of warrant liability
Expected term (in years)	6 months 7 days
Minimum | Warrants
Fair value of warrant liability
Alternative Investment, Measurement Input | $ / shares	128.00	128.00
Minimum | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input | $ / shares	6.76	6.76
Minimum | Measurement Input, Option Volatility | Warrants
Fair value of warrant liability
Alternative Investment, Measurement Input	0.4759	0.5939
Minimum | Measurement Input, Option Volatility | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input		0.4653
Minimum | Measurement Input, Risk Free Interest Rate | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input		0.0244
Minimum | Measurement Input, Expected Term | Warrants
Fair value of warrant liability
Alternative Investment, Measurement Input	0.10
Expected term (in years)		7 months 2 days
Minimum | Measurement Input, Expected Term | SARs
Fair value of warrant liability
Expected term (in years)		3 days
Maximum | Warrants
Fair value of warrant liability
Alternative Investment, Measurement Input | $ / shares	2,520.00	2,520.00
Maximum | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input | $ / shares	30.86	30.86
Maximum | Measurement Input, Option Volatility | Warrants
Fair value of warrant liability
Alternative Investment, Measurement Input	0.4841	0.6048
Maximum | Measurement Input, Option Volatility | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input		0.5959
Maximum | Measurement Input, Risk Free Interest Rate | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input		0.0263
Maximum | Measurement Input, Expected Term | Warrants
Fair value of warrant liability
Alternative Investment, Measurement Input	0.23
Expected term (in years)		8 months 19 days
Maximum | Measurement Input, Expected Term | SARs
Fair value of warrant liability
Expected term (in years)		1 year 3 days
Common stock | Measurement Input, Share Price | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input | $ / shares	45.00	34.32
Milestones and Royalties | Minimum | Probability of Success [Member] | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.25	0.25
Milestones and Royalties | Maximum | Probability of Success [Member] | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.89	0.89
Development and Regulatory Milestone | Minimum | Probability of Success [Member] | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.25	0.25
Development and Regulatory Milestone | Maximum | Probability of Success [Member] | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.94	0.94
Agilis | Milestones and Royalties
Changes in the fair value of warrant liability and SARs liability
December 31, 2018	$ 53,200
June 30, 2019	$ 58,800	$ 53,200
Agilis | Milestones and Royalties | Measurement Input, Discount Rate | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.145	0.140
Agilis | Milestones and Royalties | Minimum | Sales Milestones | Commitments
Fair value of warrant liability
Alternative Investment, Milestone	$ 0	$ 0
Agilis | Milestones and Royalties | Minimum | Percentage of Sales for Royalties | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.02	0.02
Agilis | Milestones and Royalties | Maximum | Sales Milestones | Commitments
Fair value of warrant liability
Alternative Investment, Milestone	$ 150,000	$ 150,000
Agilis | Milestones and Royalties | Maximum | Percentage of Sales for Royalties | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.06	0.06
Agilis | Development and Regulatory Milestone
Changes in the fair value of warrant liability and SARs liability
December 31, 2018	$ 257,040
June 30, 2019	277,400	$ 257,040
Agilis | Development and Regulatory Milestone | Minimum | Development and Regulatory Milestone | Commitments
Fair value of warrant liability
Alternative Investment, Milestone	$ 0	$ 0
Agilis | Development and Regulatory Milestone | Minimum | Measurement Input, Discount Rate | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.038	0.058
Agilis | Development and Regulatory Milestone | Maximum | Development and Regulatory Milestone | Commitments
Fair value of warrant liability
Alternative Investment, Milestone	$ 555,000	$ 555,000
Agilis | Development and Regulatory Milestone | Maximum | Measurement Input, Discount Rate | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.057	0.08
Significant unobservable inputs (level 3) | Agilis
Changes in the fair value of warrant liability and SARs liability
December 31, 2018	$ 53,200
June 30, 2019	58,800	$ 53,200
Significant unobservable inputs (level 3) | Agilis | Milestones and Royalties
Changes in the fair value of warrant liability and SARs liability
December 31, 2018	53,200
Additions	0
Change in fair value	5,600
Payments	0
June 30, 2019	$ 58,800	$ 53,200

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