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Stock award plan - Share Base Compensation (Details) - Stock option - USD ($)
$ / shares in Units, $ in Thousands
6 Months Ended
Jun. 30, 2019
Number of options  
Outstanding at the beginning of the period (in shares) 8,534,358
Granted (in shares) 2,845,620
Exercised (in shares) (311,002)
Forfeited/Cancelled (in shares) (215,675)
Outstanding at the end of the period (in shares) 10,853,301
Vested or Expected to vest at the end of the period (in shares) 5,334,168
Exercisable at the end of the period (in shares) 5,138,717
Weighted- average exercise price  
Outstanding at the beginning of the period (in dollars per share) $ 28.58
Granted (in dollars per share) 33.54
Exercised (in dollars per share) 16.50
Forfeited/Cancelled (in dollars per share) 36.10
Outstanding at the end of the period (in dollars per share) 30.07
Vested or Expected to vest at the end of the period (in dollars per share) 29.22
Exercisable at the end of the period (in dollars per share) $ 30.90
Weighted- average remaining contractual term  
Outstanding at the end of the period 7 years 7 months 2 days
Vested or Expected to vest at the end of the period 9 years 3 days
Exercisable at the end of the period 5 years 11 months 23 days
Aggregate intrinsic value  
Outstanding at the end of the period (in dollars) $ 178,906
Vested or Expected to vest at the end of the period (in dollars) 84,446
Exercisable at the end of the period (in dollars) $ 88,423
Minimum  
Valuation assumptions  
Risk-free interest rate (as a percent) 1.98%
Expected volatility (as a percent) 61.90%
Expected term (in years) 6 years 1 month 9 days
Maximum  
Valuation assumptions  
Risk-free interest rate (as a percent) 2.63%
Expected volatility (as a percent) 63.09%
Expected term (in years) 6 years 1 month 9 days