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Debt - Narrative (Details)		1 Months Ended		6 Months Ended
	May 05, 2017 USD ($)	May 31, 2017 USD ($)	Aug. 31, 2015 USD ($) day $ / shares	Jun. 30, 2019 USD ($)	Jun. 30, 2018 USD ($)	Dec. 31, 2018 USD ($)
Long-term debt
Repayments of Debt				$ 1,667,000	$ 0
Convertible debt | 3.00% Convertible senior notes due 2022
Long-term debt
Debt principal amount			$ 150,000,000.0	150,000,000		$ 150,000,000
Interest rate ( as a percent )			3.00%
Net proceeds from issuance of convertible notes			$ 145,400,000
Trading days, number | day			20
Consecutive trading days, period | day			30
Stock price trigger			130.00%
Business days, period			5 days
Consecutive trading-day period			5 days
Common stock per principal amount			$ 1,000
Maximum product of the closing sale price of shares of the Company's common stock and the applicable conversion rate for such trading day			98.00%
Conversion ratio			17.7487
Conversion price per share (in dollars per share) | $ / shares			$ 56.34
Convertible instruments principal and unpaid interest payable upon events of default			100.00%
Minimum percentage of principal held by convertible debt instrument holders required to issue notice for declaration of principal and unpaid interest payable upon events of default			25.00%
Term of the convertible notes			7 years
Adjustments to additional paid in capital, equity component of convertible debt			$ 57,500,000
Net deferred tax liability in connection with convertible notes			$ 22,300,000
Fair value of convertible notes				$ 166,200,000		$ 146,600,000
Remaining contractual life of the convertible notes				3 years 1 month 6 days
Convertible debt | 3.00% Convertible senior notes due 2022 | Redemption on or after August 20, 2018
Long-term debt
Trading days, number | day			19
Consecutive trading days, period | day			30
Stock price trigger			130.00%
Redemption price			100.00%
Sinking fund			$ 0
MidCap Financial Trust
Long-term debt
Line of credit facility, maximum borrowing capacity		$ 60,000,000.0
Proceeds from lines of credit	$ 40,000,000.0
Line of credit facility, additional capacity available, net product revenue threshold		20,000,000.0
Debt issuance costs		$ 400,000
Repayments of Debt				$ 1,700,000
Debt instrument, floor interest rate		1.00%
Debt instrument, basis spread on variable rate		6.15%
Debt instrument, interest payment period		24 months

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