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Intangible assets and goodwill - Narrative (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2019
Jun. 30, 2018
Jun. 30, 2019
Jun. 30, 2018
Dec. 31, 2018
Apr. 20, 2017
Finite-Lived Intangible Assets [Line Items]            
Useful life     7 years      
Amortization of acquired intangible assets $ 6,575 $ 5,593 $ 12,652 $ 11,022    
Total allocation of IPR&D assets     576,500      
Goodwill 82,341   82,341   $ 82,341  
Research and development 59,979 32,607 112,544 63,970    
Akcea            
Finite-Lived Intangible Assets [Line Items]            
Milestone, Potential Achievements, Regulatory Approval 4,000   4,000      
Upfront licensing fee     12,000      
Non-collaborative Arrangement Transactions | Akcea            
Finite-Lived Intangible Assets [Line Items]            
Milestone, Potential Achievements, Regulatory Approval 6,000   $ 6,000      
Useful life     10 years      
Emflaza asset acquisition            
Finite-Lived Intangible Assets [Line Items]            
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Finite-Lived Intangibles           $ 148,400
Milestone, Potential Achievements, Regulatory Approval $ 8,300 $ 3,900 $ 8,300 $ 3,900