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Consolidated Statements of Stockholders' Equity - USD ($)
Total
Common stock
Additional paid-in capital
AOCI Attributable to Parent
Accumulated deficit
Balance (in shares) at Dec. 31, 2017   41,612,395      
Balance at the beginning of the period at Dec. 31, 2017 $ 156,437,000 $ 42,000 $ 966,534,000 $ 3,969,000 $ (814,108,000)
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock related to equity offering (in shares)   4,600,000      
Issuance of common stock related to equity offering 117,874,000 $ 5,000 117,869,000    
Exercised (in shares)   260,879      
Exercise of options 3,592,000 $ 0 3,592,000    
Issuance of restricted stock (in shares)   119,691      
Restricted stock vesting and issuance 0        
Issuance of common stock in connection with an employee stock purchase plan (in shares)   87,517      
Issuance of common stock in connection with an employee stock purchase plan 1,299,000 $ 0 1,299,000    
Share-based compensation expense 15,831,000   15,831,000    
Net loss (28,782,000)       (28,782,000)
Comprehensive income (2,114,000)     (2,114,000)  
Balance (in shares) at Jun. 30, 2018   46,680,482      
Balance at the end of the period at Jun. 30, 2018 267,402,000 $ 47,000 1,105,124,000 1,855,000 (839,624,000)
Balance (in shares) at Mar. 31, 2018   41,809,398      
Balance at the beginning of the period at Mar. 31, 2018 150,309,000 $ 42,000 975,418,000 4,953,000 (830,104,000)
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock related to equity offering (in shares)   4,600,000      
Issuance of common stock related to equity offering 117,874,000 $ 5,000 117,869,000    
Exercised (in shares)   183,567      
Exercise of options 2,455,000   2,455,000    
Restricted stock vesting and issuance 0        
Issuance of common stock in connection with an employee stock purchase plan (in shares)   87,517      
Issuance of common stock in connection with an employee stock purchase plan 1,298,000 $ 0 1,298,000    
Share-based compensation expense 8,084,000   8,084,000    
Net loss (9,520,000)       (9,520,000)
Comprehensive income (3,098,000)     (3,098,000)  
Balance (in shares) at Jun. 30, 2018   46,680,482      
Balance at the end of the period at Jun. 30, 2018 267,402,000 $ 47,000 1,105,124,000 1,855,000 (839,624,000)
Increase (Decrease) in Stockholders' Equity          
Adjustment to accumulated deficit 3,265,000   (1,000)   3,266,000
Balance (in shares) at Dec. 31, 2018   50,606,147      
Balance at the beginning of the period at Dec. 31, 2018 350,727,000 $ 51,000 1,288,137,000 1,462,000 (938,923,000)
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock related to equity offering (in shares)   7,563,725      
Issuance of common stock related to equity offering 224,545,000 $ 7,000 224,538,000    
Exercised (in shares)   311,002      
Exercise of options 4,129,000 $ 0 4,129,000    
Restricted stock vesting and issuance (in shares)   171,592      
Restricted stock vesting and issuance 0 $ 0      
Issuance of common stock in connection with an employee stock purchase plan (in shares)   54,719      
Issuance of common stock in connection with an employee stock purchase plan 1,564,000 $ 0 1,564,000    
Share-based compensation expense 20,184,000   20,184,000    
Adjustments to Additional Paid In Capital, Receivable from Investor 978,000   978,000    
Net loss (113,902,000)       (113,902,000)
Comprehensive income 460,000     460,000  
Balance (in shares) at Jun. 30, 2019   58,707,185      
Balance at the end of the period at Jun. 30, 2019 488,685,000 $ 58,000 1,539,530,000 1,922,000 (1,052,825,000)
Balance (in shares) at Mar. 31, 2019   58,418,790      
Balance at the beginning of the period at Mar. 31, 2019 512,942,000 $ 58,000 1,523,115,000 805,000 (1,011,036,000)
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock related to equity offering (in shares)   0      
Issuance of common stock related to equity offering 106,000 $ 0 106,000    
Exercised (in shares)   230,176      
Exercise of options 2,847,000 $ 0 2,847,000    
Restricted stock vesting and issuance (in shares)   3,500      
Issuance of common stock in connection with an employee stock purchase plan (in shares)   54,719      
Issuance of common stock in connection with an employee stock purchase plan 1,564,000 $ 0 1,564,000    
Share-based compensation expense 10,920,000   10,920,000    
Adjustments to Additional Paid In Capital, Receivable from Investor 978,000   978,000    
Net loss (41,789,000)       (41,789,000)
Comprehensive income 1,117,000     1,117,000  
Balance (in shares) at Jun. 30, 2019   58,707,185      
Balance at the end of the period at Jun. 30, 2019 $ 488,685,000 $ 58,000 $ 1,539,530,000 $ 1,922,000 $ (1,052,825,000)