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Commitments and contingencies - Narrative (Details) - USD ($) $ in Millions | 9 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | ---
Sep. 30, 2019 | Dec. 31, 2018 | Aug. 23, 2018 | Jun. 30, 2016
Akcea |  |  |  |
Other Commitments [Abstract] |  |  |  |
Upfront licensing fee | $ 12.0 |  |  |
Milestone payments | 4.0 |  |  |
Akcea | Maximum |  |  |  |
Other Commitments [Abstract] |  |  |  |
Milestone payments | 8.0 |  |  |
Non-collaborative Arrangement Transactions | Akcea |  |  |  |
Other Commitments [Abstract] |  |  |  |
Milestone payments | 6.0 |  |  |
Agilis |  |  |  |
Other Commitments [Abstract] |  |  |  |
Development milestone payments which the entity is obligated to pay |  | $ 40.0 | $ 40.0 |
Agilis | Maximum |  |  |  |
Other Commitments [Abstract] |  |  |  |
Development milestone payments which the entity is obligated to pay | 60.0 | 60.0 |  |
Priority review voucher amount | 535.0 | 535.0 |  |
Net sales amount | $ 150.0 | $ 150.0 |  |
Product sales | 6.00% | 6.00% |  |
Agilis | Non-collaborative Arrangement Transactions |  |  |  |
Other Commitments [Abstract] |  |  |  |
Development milestone payments which the entity is obligated to pay | $ 40.0 |  |  |
Product | Wellcome trust |  |  |  |
Other Commitments [Abstract] |  |  |  |
Development milestone payments which the entity is obligated to pay |  |  |  | $ 0.8
Product | Wellcome trust | Maximum |  |  |  |
Other Commitments [Abstract] |  |  |  |
Development milestone payments which the entity is obligated to pay | $ 22.4 |  |  |

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- Definition Contingent Liability, Milestone, Potential Achievements, Net Sales Milestone And Regulatory Approval + References No definition available. + Details
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- Definition Contingent Liability, Milestone, Potential Achievements, Priority Review Voucher Amount + References No definition available. + Details
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- Definition Contingent Liability, Milestone, Potential Achievements, Product Sales Percentage + References No definition available. + Details
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- Definition Represents the development milestones payments which the entity is obligated to pay under certain contractual agreements. + References No definition available. + Details
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- Definition Milestone payment which the entity is obliged to pay upon regulatory approval + References No definition available. + Details
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- Definition Upfront Licensing Fee + References No definition available. + Details
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- References No definition available. + Details
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- Details
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- Details
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- Details
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- Details
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- Details
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- Details
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