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Revenue recognition - Narrative (Details) | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | ---
Oct. 31, 2017 USD ($) | Nov. 30, 2014 USD ($) | Jan. 31, 2014 USD ($) | Aug. 31, 2013 USD ($) | Nov. 30, 2011 USD ($) compound | Sep. 30, 2019 USD ($) | Sep. 30, 2018 USD ($) | Sep. 30, 2019 USD ($) deliverable segment | Sep. 30, 2018 USD ($) | Dec. 31, 2017 USD ($) deliverable | Dec. 31, 2018 USD ($)
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |
Contract with Customer, Liability |  |  |  |  |  | $ 14,306,000 | $ 12,660,000 | $ 14,306,000 | $ 12,660,000 | $ 11,891,000 | $ 12,938,000
Number of operating segments | segment |  |  |  |  |  |  |  | 1 |  |  |
Net product revenue |  |  |  |  |  | 71,369,000 | 53,021,000 | $ 209,899,000 | 177,172,000 |  |
Upfront cash payment |  |  |  |  |  |  |  | 3,801,000 | 4,706,000 |  |
Revenue |  |  |  |  |  | 71,416,000 | 53,591,000 | 210,521,000 | 178,396,000 |  |
Performance obligations satisfied in current period |  |  |  |  |  | 69,100,000 | 53,021,000 | 207,630,000 | 177,172,000 |  |
Licensing And Collaboration Agreement |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |
Upfront cash payment |  |  |  |  | $ 30,000,000.0 |  |  |  |  |  |
Performance obligations satisfied in current period | $ 20,000,000.0 | $ 10,000,000 | $ 7,500,000 | $ 10,000,000.0 |  |  |  |  |  |  |
Licensing And Collaboration Agreement | Research And Development Event Milestones |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue recognition, milestone, potential achievements |  |  |  |  | 135,000,000.0 |  |  | 87,500,000 |  |  |
Licensing And Collaboration Agreement | Sales Milestones |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue recognition, milestone, potential achievements |  |  |  |  | $ 325,000,000.0 |  |  | 325,000,000.0 |  |  |
Discovery Agreements |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  | 0 | 0 |  |
Early Stage Collaborations |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  | 0 | 0 |  |
Early Stage Collaborations | Research And Development Event Milestones |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue recognition, milestone, potential achievements |  |  |  |  |  |  |  | 143,000,000.0 |  |  |
Early Stage Collaborations | Sales Milestones |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue recognition, milestone, potential achievements |  |  |  |  |  |  |  | 252,000,000.0 |  |  |
United States |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |
Net product revenue |  |  |  |  |  | 22,900,000 | 22,600,000 | 68,300,000 | 62,200,000 |  |
Non-US |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |
Net product revenue |  |  |  |  |  | 48,500,000 | 30,400,000 | $ 141,600,000 | 115,000,000.0 |  |
Collaborative Arrangement | Roche And Sma Foundation |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |
Number of compounds in preclinical development | compound |  |  |  |  | 3 |  |  |  |  |  |
Number of significant deliverables | deliverable |  |  |  |  |  |  |  |  |  | 2 |
Collaboration And Discovery Agreements |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |
Number of significant deliverables | deliverable |  |  |  |  |  |  |  | 2 |  |  |
Minimum | Collaboration And Discovery Agreements |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |
Collaborative arrangements research period for applying discovery technology |  |  |  |  |  |  |  | 3 years |  |  |
Maximum | Collaboration And Discovery Agreements |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |
Collaborative arrangements research period for applying discovery technology |  |  |  |  |  |  |  | 4 years |  |  |
Roche | Licensing And Collaboration Agreement |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  | $ 100,000 | $ 100,000 | $ 100,000 | $ 200,000 |  |

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