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v3.19.3

Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2019 | Sep. 30, 2018
Cash flows from operating activities |  |
Net loss | $ (173,899) | $ (79,751)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 22,903 | 19,316
Change in valuation of warrant liability | 0 | 3
Change in valuation of deferred and contingent consideration | 35,960 | 0
Unrealized gain on MRI investment | (2,529) | 0
Non-cash interest expense | 6,583 | 5,563
Loss on disposal of asset | 0 | 2
Amortization of discounts on investments, net | (1,374) | (354)
Amortization of debt issuance costs | 434 | 390
Share-based compensation expense | 30,668 | 24,773
Unrealized foreign currency transaction losses (gains), net | 205 | (977)
Changes in operating assets and liabilities: |  |
Inventory | (1,574) | (3,252)
Prepaid expenses and other current assets | (11,771) | (1,301)
Trade receivables, net | 5,879 | (2,681)
Deposits and other assets | (14,747) | (385)
Accounts payable and accrued expenses | 695 | 18,606
Other liabilities | 12,553 | 1,617
Deferred revenue | 1,581 | 5,933
Net cash used in operating activities | (88,433) | (12,498)
Cash flows from investing activities |  |
Purchases of fixed assets | (9,104) | (2,489)
Purchases of equity investment in MRI | (4,000) | 0
Purchases of marketable securities | (239,386) | (28,656)
Sale and redemption of marketable securities | 114,500 | 65,923
Acquisition of product rights and licenses | (20,250) | (3,903)
Business acquisition, net of cash acquired | 0 | (48,892)
Net cash used in investing activities | (158,240) | (18,017)
Cash flows from financing activities |  |
Proceeds from exercise of options | 12,195 | 8,631
Net proceeds from public offerings | 324,262 | 117,915
Proceeds from Convertible Debt | 279,571 | 0
Proceeds from shares issued under employee stock purchase plan | 1,564 | 1,299
Repayments of Secured Debt | (6,667) | 0
Net cash provided by financing activities | 610,925 | 127,845
Effect of exchange rate changes on cash | (2,673) | (2,209)
Net increase in cash and cash equivalents | 361,579 | 95,121
Cash and cash equivalents, and restricted cash beginning of period | 169,498 | 111,792
Cash and cash equivalents, and restricted cash end of period | 523,577 |
Supplemental disclosure of cash information |  |
Cash paid for interest | 7,042 | 6,927
Cash paid for income taxes | 1,931 | 919
Supplemental disclosure of non-cash investing and financing activity |  |
Unrealized (loss) gain on marketable securities | 435 | (50)
Right-of-use assets obtained in exchange for lease obligations | 16,120 | 0
Acquisition of product rights and licenses | 7,432 | 4,530
Accrued transaction costs related to public offerings | 506 | 0
Accrued transaction costs related to issuance of convertible notes | $ 298 | $ 0

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