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Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands | Total | Common stock | Additional paid-in capital | AOCI Attributable to Parent | Accumulated deficit
--- | --- | --- | --- | --- | ---
Balance (in shares) at Dec. 31, 2017 |  | 41,612,395 |  |  |
Balance at the beginning of the period at Dec. 31, 2017 | $ 156,437 | $ 42 | $ 966,534 | $ 3,969 | $ (814,108)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock related to equity offering (in shares) |  | 4,600,000 |  |  |
Issuance of common stock related to equity offerings | 117,915 | $ 4 | 117,911 |  |
Issuance of common stock related to acquisition (in shares) |  | 3,500,907 |  |  |
Issuance of common stock related to acquisition | 155,861 | $ 4 | 155,857 |  |
Exercised (in shares) |  | 512,145 |  |  |
Exercise of options | 8,631 | $ 1 | 8,630 |  |
Restricted stock vesting and issuance (in shares) |  | 119,691 |  |  |
Restricted stock vesting and issuance | 0 |  |  |  |
Issuance of common stock in connection with an employee stock purchase plan (in shares) |  | 87,517 |  |  |
Issuance of common stock in connection with an employee stock purchase plan | 1,299 |  | 1,299 |  |
Share-based compensation expense | 24,773 |  | 24,773 |  |
Net loss | (79,751) |  |  |  | (79,751)
Comprehensive income | (2,341) |  |  | (2,341) |
Balance (in shares) at Sep. 30, 2018 |  | 50,432,655 |  |  |
Balance at the end of the period at Sep. 30, 2018 | 386,090 | $ 51 | 1,275,004 | 1,628 | (890,593)
Balance (in shares) at Dec. 31, 2017 |  | 41,612,395 |  |  |
Balance at the beginning of the period at Dec. 31, 2017 | 156,437 | $ 42 | 966,534 | 3,969 | (814,108)
Balance (in shares) at Dec. 31, 2018 |  | 50,606,147 |  |  |
Balance at the end of the period at Dec. 31, 2018 | 350,727 | $ 51 | 1,288,137 | 1,462 | (938,923)
Balance (in shares) at Jun. 30, 2018 |  | 46,680,482 |  |  |
Balance at the beginning of the period at Jun. 30, 2018 | 267,402 | $ 47 | 1,105,124 | 1,855 | (839,624)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock related to equity offerings | 42 |  | 42 |  |
Issuance of common stock related to acquisition (in shares) |  | 3,500,907 |  |  |
Issuance of common stock related to acquisition | 155,861 | $ 4 | 155,857 |  |
Exercised (in shares) |  | 251,266 |  |  |
Exercise of options | 5,039 |  | 5,039 |  |
Share-based compensation expense | 8,942 |  | 8,942 |  |
Net loss | (50,969) |  |  |  | (50,969)
Comprehensive income | (227) |  |  | (227) |
Balance (in shares) at Sep. 30, 2018 |  | 50,432,655 |  |  |
Balance at the end of the period at Sep. 30, 2018 | 386,090 | $ 51 | 1,275,004 | 1,628 | (890,593)
Balance (in shares) at Dec. 31, 2018 |  | 50,606,147 |  |  |
Balance at the beginning of the period at Dec. 31, 2018 | 350,727 | $ 51 | 1,288,137 | 1,462 | (938,923)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock related to equity offering (in shares) |  | 10,102,899 |  |  |
Issuance of common stock related to equity offerings | 323,756 | $ 10 | 323,746 |  |
Adjustments to additional paid in capital, equity component of convertible debt | 119,489 |  | 119,489 |  |
Exercised (in shares) |  | 645,435 |  |  |
Exercise of options | 12,195 |  | 12,195 |  |
Restricted stock vesting and issuance, net (in shares) |  | 169,792 |  |  |
Restricted stock vesting and issuance, net | 0 |  |  |  |
Issuance of common stock in connection with an employee stock purchase plan (in shares) |  | 54,719 |  |  |
Issuance of common stock in connection with an employee stock purchase plan | 1,564 |  | 1,564 |  |
Share-based compensation expense | 30,668 |  | 30,668 |  |
Net loss | (173,899) |  |  |  | (173,899)
Comprehensive income | (846) |  |  | (846) |
Balance (in shares) at Sep. 30, 2019 |  | 61,578,992 |  |  |
Balance at the end of the period at Sep. 30, 2019 | 663,654 | $ 61 | 1,775,799 | 616 | (1,112,822)
Balance (in shares) at Jun. 30, 2019 |  | 58,707,185 |  |  |
Balance at the beginning of the period at Jun. 30, 2019 | 488,685 | $ 58 | 1,539,530 | 1,922 | (1,052,825)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock related to equity offering (in shares) |  | 2,539,174 |  |  |
Issuance of common stock related to equity offerings | 99,211 | $ 3 | 99,208 |  |
Adjustments to additional paid in capital, equity component of convertible debt | 119,489 |  | 119,489 |  |
Exercised (in shares) |  | 334,433 |  |  |
Exercise of options | 7,088 | $ 0 | 7,088 |  |
Restricted stock vesting and issuance, net (in shares) |  | (1,800) |  |  |
Restricted stock vesting and issuance, net | 0 |  |  |  |
Share-based compensation expense | 10,484 |  | 10,484 |  |
Net loss | (59,997) |  |  |  |
Comprehensive income | (1,306) |  |  | (1,306) |
Balance (in shares) at Sep. 30, 2019 |  | 61,578,992 |  |  |
Balance at the end of the period at Sep. 30, 2019 | $ 663,654 | $ 61 | $ 1,775,799 | $ 616 | $ (1,112,822)

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