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Fair value of financial instruments and marketable securities - Warrants and SARs (Details) $ in Thousands | 9 Months Ended | 12 Months Ended
--- | --- | ---
Sep. 30, 2019 USD ($) $ / shares | Dec. 31, 2018 USD ($) $ / shares
Changes in the fair value of warrant liability and SARs liability |  |
Additions | $ 0 |
SARs |  |
Changes in the fair value of warrant liability and SARs liability |  |
December 31, 2018 | 3,814 |
Change in fair value | 2,236 |
Payments | (3,815) |
September 30, 2019 | 2,235 | $ 3,814
Commitments |  |
Changes in the fair value of warrant liability and SARs liability |  |
December 31, 2018 | 257,040 |
Additions | 0 |
Change in fair value | 28,260 |
Payments | 0 |
September 30, 2019 | 285,300 | 257,040
SARs |  |
Changes in the fair value of warrant liability and SARs liability |  |
December 31, 2018 | 3,814 |
September 30, 2019 | $ 2,235 | $ 3,814
Measurement Input, Risk Free Interest Rate | SARs |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.0188 |
Measurement Input, Expected Term | SARs |  |
Fair value of warrant liability |  |
Expected term (in years) | 3 months 3 days |
Minimum | SARs |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | $ / shares | 6.76 | 6.76
Minimum | Measurement Input, Option Volatility | SARs |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.4323 | 0.4653
Minimum | Measurement Input, Risk Free Interest Rate | SARs |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input |  | 0.0244
Minimum | Measurement Input, Expected Term | SARs |  |
Fair value of warrant liability |  |
Expected term (in years) |  | 3 days
Maximum | SARs |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | $ / shares | 30.86 | 30.86
Maximum | Measurement Input, Option Volatility | SARs |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input |  | 0.5959
Maximum | Measurement Input, Risk Free Interest Rate | SARs |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input |  | 0.0263
Maximum | Measurement Input, Expected Term | SARs |  |
Fair value of warrant liability |  |
Expected term (in years) |  | 1 year 3 days
Common stock | Measurement Input, Share Price | SARs |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | $ / shares | 33.82 | 34.32
Milestones and Royalties | Minimum | Probability of Success [Member] | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.25 | 0.25
Milestones and Royalties | Maximum | Probability of Success [Member] | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.89 | 0.89
Development and Regulatory Milestone | Minimum | Probability of Success [Member] | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.25 | 0.25
Development and Regulatory Milestone | Maximum | Probability of Success [Member] | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.94 | 0.94
Agilis | Milestones and Royalties |  |
Changes in the fair value of warrant liability and SARs liability |  |
December 31, 2018 | $ 53,200 |
September 30, 2019 | $ 59,600 | $ 53,200
Agilis | Milestones and Royalties | Measurement Input, Discount Rate | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.140 | 0.140
Agilis | Milestones and Royalties | Minimum | Sales Milestones | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Milestone | $ 0 | $ 0
Agilis | Milestones and Royalties | Minimum | Percentage of Sales for Royalties | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.02 | 0.02
Agilis | Milestones and Royalties | Maximum | Sales Milestones | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Milestone | $ 150,000 | $ 150,000
Agilis | Milestones and Royalties | Maximum | Percentage of Sales for Royalties | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.06 | 0.06
Agilis | Development and Regulatory Milestone |  |
Changes in the fair value of warrant liability and SARs liability |  |
December 31, 2018 | $ 257,040 |
September 30, 2019 | 285,300 | $ 257,040
Agilis | Development and Regulatory Milestone | Minimum | Development and Regulatory Milestone | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Milestone | $ 0 | $ 0
Agilis | Development and Regulatory Milestone | Minimum | Measurement Input, Discount Rate | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.027 | 0.058
Agilis | Development and Regulatory Milestone | Maximum | Development and Regulatory Milestone | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Milestone | $ 555,000 | $ 555,000
Agilis | Development and Regulatory Milestone | Maximum | Measurement Input, Discount Rate | Commitments |  |
Fair value of warrant liability |  |
Alternative Investment, Measurement Input | 0.051 | 0.08
Significant unobservable inputs (level 3) | Agilis |  |
Changes in the fair value of warrant liability and SARs liability |  |
December 31, 2018 | $ 53,200 |
September 30, 2019 | 59,600 | $ 53,200
Significant unobservable inputs (level 3) | Agilis | Milestones and Royalties |  |
Changes in the fair value of warrant liability and SARs liability |  |
December 31, 2018 | 53,200 |
Additions | 0 |
Change in fair value | 6,400 |
Payments | 0 |
September 30, 2019 | $ 59,600 | $ 53,200

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