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Consolidated Statements of Operations (unaudited) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2019
Sep. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Revenues:        
Revenue $ 71,416 $ 53,591 $ 210,521 $ 178,396
Operating expenses:        
Cost of product sales, excluding amortization of acquired intangible assets 3,006 3,292 8,593 8,909
Amortization of acquired intangible assets 7,025 5,793 19,677 16,815
Research and development 63,076 54,368 175,621 118,337
Selling, general and administrative 49,284 38,368 139,044 104,882
Change in the fair value of deferred and contingent consideration 9,500 0 35,960 0
Total operating expenses 131,891 101,821 378,895 248,943
Loss from operations (60,475) (48,230) (168,374) (70,547)
Interest expense, net (2,666) (3,118) (7,028) (9,306)
Other income, net 2,800 734 2,509 1,066
Loss before income tax expense (60,341) (50,614) (172,893) (78,787)
Income tax benefit (expense) 344 (355) (1,006) (964)
Net loss attributable to common stockholders $ (59,997) $ (50,969) $ (173,899) $ (79,751)
Weighted-average shares outstanding:        
Basic and diluted (in shares) 56,463,528 48,096,521 57,798,968 45,310,690
Net loss per share-basic and diluted (in dollars per share)        
Net loss per share—basic and diluted (in dollars per share) $ (1.06) $ (1.06) $ (3.01) $ (1.76)
Net product revenue        
Revenues:        
Revenue $ 71,369 $ 53,021 $ 209,899 $ 177,172
Collaboration and grant revenue        
Revenues:        
Revenue $ 47 $ 570 $ 622 $ 1,224