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Fair value of financial instruments and marketable securities - Warrants and SARs (Details) $ in Thousands	9 Months Ended	12 Months Ended
	Sep. 30, 2019 USD ($) $ / shares	Dec. 31, 2018 USD ($) $ / shares
Changes in the fair value of warrant liability and SARs liability
Additions	$ 0
SARs
Changes in the fair value of warrant liability and SARs liability
December 31, 2018	3,814
Change in fair value	2,236
Payments	(3,815)
September 30, 2019	2,235	$ 3,814
Commitments
Changes in the fair value of warrant liability and SARs liability
December 31, 2018	257,040
Additions	0
Change in fair value	28,260
Payments	0
September 30, 2019	285,300	257,040
SARs
Changes in the fair value of warrant liability and SARs liability
December 31, 2018	3,814
September 30, 2019	$ 2,235	$ 3,814
Measurement Input, Risk Free Interest Rate | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input	0.0188
Measurement Input, Expected Term | SARs
Fair value of warrant liability
Expected term (in years)	3 months 3 days
Minimum | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input | $ / shares	6.76	6.76
Minimum | Measurement Input, Option Volatility | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input	0.4323	0.4653
Minimum | Measurement Input, Risk Free Interest Rate | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input		0.0244
Minimum | Measurement Input, Expected Term | SARs
Fair value of warrant liability
Expected term (in years)		3 days
Maximum | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input | $ / shares	30.86	30.86
Maximum | Measurement Input, Option Volatility | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input		0.5959
Maximum | Measurement Input, Risk Free Interest Rate | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input		0.0263
Maximum | Measurement Input, Expected Term | SARs
Fair value of warrant liability
Expected term (in years)		1 year 3 days
Common stock | Measurement Input, Share Price | SARs
Fair value of warrant liability
Alternative Investment, Measurement Input | $ / shares	33.82	34.32
Milestones and Royalties | Minimum | Probability of Success [Member] | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.25	0.25
Milestones and Royalties | Maximum | Probability of Success [Member] | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.89	0.89
Development and Regulatory Milestone | Minimum | Probability of Success [Member] | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.25	0.25
Development and Regulatory Milestone | Maximum | Probability of Success [Member] | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.94	0.94
Agilis | Milestones and Royalties
Changes in the fair value of warrant liability and SARs liability
December 31, 2018	$ 53,200
September 30, 2019	$ 59,600	$ 53,200
Agilis | Milestones and Royalties | Measurement Input, Discount Rate | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.140	0.140
Agilis | Milestones and Royalties | Minimum | Sales Milestones | Commitments
Fair value of warrant liability
Alternative Investment, Milestone	$ 0	$ 0
Agilis | Milestones and Royalties | Minimum | Percentage of Sales for Royalties | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.02	0.02
Agilis | Milestones and Royalties | Maximum | Sales Milestones | Commitments
Fair value of warrant liability
Alternative Investment, Milestone	$ 150,000	$ 150,000
Agilis | Milestones and Royalties | Maximum | Percentage of Sales for Royalties | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.06	0.06
Agilis | Development and Regulatory Milestone
Changes in the fair value of warrant liability and SARs liability
December 31, 2018	$ 257,040
September 30, 2019	285,300	$ 257,040
Agilis | Development and Regulatory Milestone | Minimum | Development and Regulatory Milestone | Commitments
Fair value of warrant liability
Alternative Investment, Milestone	$ 0	$ 0
Agilis | Development and Regulatory Milestone | Minimum | Measurement Input, Discount Rate | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.027	0.058
Agilis | Development and Regulatory Milestone | Maximum | Development and Regulatory Milestone | Commitments
Fair value of warrant liability
Alternative Investment, Milestone	$ 555,000	$ 555,000
Agilis | Development and Regulatory Milestone | Maximum | Measurement Input, Discount Rate | Commitments
Fair value of warrant liability
Alternative Investment, Measurement Input	0.051	0.08
Significant unobservable inputs (level 3) | Agilis
Changes in the fair value of warrant liability and SARs liability
December 31, 2018	$ 53,200
September 30, 2019	59,600	$ 53,200
Significant unobservable inputs (level 3) | Agilis | Milestones and Royalties
Changes in the fair value of warrant liability and SARs liability
December 31, 2018	53,200
Additions	0
Change in fair value	6,400
Payments	0
September 30, 2019	$ 59,600	$ 53,200

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