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Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Total
Common stock
Additional paid-in capital
AOCI Attributable to Parent
Accumulated deficit
Balance (in shares) at Dec. 31, 2017   41,612,395      
Balance at the beginning of the period at Dec. 31, 2017 $ 156,437 $ 42 $ 966,534 $ 3,969 $ (814,108)
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock related to equity offering (in shares)   4,600,000      
Issuance of common stock related to equity offerings 117,915 $ 4 117,911    
Issuance of common stock related to acquisition (in shares)   3,500,907      
Issuance of common stock related to acquisition 155,861 $ 4 155,857    
Exercised (in shares)   512,145      
Exercise of options 8,631 $ 1 8,630    
Restricted stock vesting and issuance (in shares)   119,691      
Restricted stock vesting and issuance 0        
Issuance of common stock in connection with an employee stock purchase plan (in shares)   87,517      
Issuance of common stock in connection with an employee stock purchase plan 1,299   1,299    
Share-based compensation expense 24,773   24,773    
Net loss (79,751)       (79,751)
Comprehensive income (2,341)     (2,341)  
Balance (in shares) at Sep. 30, 2018   50,432,655      
Balance at the end of the period at Sep. 30, 2018 386,090 $ 51 1,275,004 1,628 (890,593)
Balance (in shares) at Dec. 31, 2017   41,612,395      
Balance at the beginning of the period at Dec. 31, 2017 156,437 $ 42 966,534 3,969 (814,108)
Balance (in shares) at Dec. 31, 2018   50,606,147      
Balance at the end of the period at Dec. 31, 2018 350,727 $ 51 1,288,137 1,462 (938,923)
Balance (in shares) at Jun. 30, 2018   46,680,482      
Balance at the beginning of the period at Jun. 30, 2018 267,402 $ 47 1,105,124 1,855 (839,624)
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock related to equity offerings 42   42    
Issuance of common stock related to acquisition (in shares)   3,500,907      
Issuance of common stock related to acquisition 155,861 $ 4 155,857    
Exercised (in shares)   251,266      
Exercise of options 5,039   5,039    
Share-based compensation expense 8,942   8,942    
Net loss (50,969)       (50,969)
Comprehensive income (227)     (227)  
Balance (in shares) at Sep. 30, 2018   50,432,655      
Balance at the end of the period at Sep. 30, 2018 386,090 $ 51 1,275,004 1,628 (890,593)
Balance (in shares) at Dec. 31, 2018   50,606,147      
Balance at the beginning of the period at Dec. 31, 2018 350,727 $ 51 1,288,137 1,462 (938,923)
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock related to equity offering (in shares)   10,102,899      
Issuance of common stock related to equity offerings 323,756 $ 10 323,746    
Adjustments to additional paid in capital, equity component of convertible debt 119,489   119,489    
Exercised (in shares)   645,435      
Exercise of options 12,195   12,195    
Restricted stock vesting and issuance, net (in shares)   169,792      
Restricted stock vesting and issuance, net 0        
Issuance of common stock in connection with an employee stock purchase plan (in shares)   54,719      
Issuance of common stock in connection with an employee stock purchase plan 1,564   1,564    
Share-based compensation expense 30,668   30,668    
Net loss (173,899)       (173,899)
Comprehensive income (846)     (846)  
Balance (in shares) at Sep. 30, 2019   61,578,992      
Balance at the end of the period at Sep. 30, 2019 663,654 $ 61 1,775,799 616 (1,112,822)
Balance (in shares) at Jun. 30, 2019   58,707,185      
Balance at the beginning of the period at Jun. 30, 2019 488,685 $ 58 1,539,530 1,922 (1,052,825)
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock related to equity offering (in shares)   2,539,174      
Issuance of common stock related to equity offerings 99,211 $ 3 99,208    
Adjustments to additional paid in capital, equity component of convertible debt 119,489   119,489    
Exercised (in shares)   334,433      
Exercise of options 7,088 $ 0 7,088    
Restricted stock vesting and issuance, net (in shares)   (1,800)      
Restricted stock vesting and issuance, net 0        
Share-based compensation expense 10,484   10,484    
Net loss (59,997)        
Comprehensive income (1,306)     (1,306)  
Balance (in shares) at Sep. 30, 2019   61,578,992      
Balance at the end of the period at Sep. 30, 2019 $ 663,654 $ 61 $ 1,775,799 $ 616 $ (1,112,822)